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利用纳米封装技术开发具有抗病毒和增强大脑功能特性的多酚和蛋白质——引出对抗新冠疫情的协同策略。

Exploitation of polyphenols and proteins using nanoencapsulation for anti-viral and brain boosting properties - Evoking a synergistic strategy to combat COVID-19 pandemic.

作者信息

Noor Nairah, Gani Adil, Gani Asir, Shah Asima, Ashraf Zanoor Ul

机构信息

Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.

Laboratory of Functional Food and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India; Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, United States.

出版信息

Int J Biol Macromol. 2021 Jun 1;180:375-384. doi: 10.1016/j.ijbiomac.2021.03.028. Epub 2021 Mar 11.

Abstract

The world is currently under the threat of COVID pandemic and has focused every dimension of research in finding a cure to this novel disease. In this current situation, people are facing mental stress, agony, fear, depression and other associated symptoms which are taking a toll on their overall mental health. Nanoencapsulation of certain brain boosting polyphenols including quercetin, caffeine, cocoa flavanols and proteins like lectins can become new area of interest in the present scenario. Besides the brain boosting benefits, we have also highlighted the anti- viral activities of these compounds which we assume can play a possible role in combating COVID-19 given to their previous history of action against certain viruses. This review outlines the nanoencapsulation approaches of such synergistic compounds as a novel strategy to take the ongoing research a step ahead and also provides a new insight in bringing the role of nanotechnology in addressing the issues related to COVID pandemic.

摘要

当前,世界正面临新冠疫情的威胁,各个研究领域都聚焦于寻找治疗这种新型疾病的方法。在当前形势下,人们正面临精神压力、痛苦、恐惧、抑郁及其他相关症状,这些都对他们的整体心理健康造成了损害。对某些具有增强大脑功能的多酚(包括槲皮素、咖啡因、可可黄烷醇)以及像凝集素这样的蛋白质进行纳米封装,可能会成为当前情形下新的研究热点。除了具有增强大脑功能的益处外,我们还强调了这些化合物的抗病毒活性,鉴于它们以往对某些病毒的作用历史,我们认为它们可能在对抗新冠病毒中发挥作用。本综述概述了此类协同化合物的纳米封装方法,作为一种新策略推动正在进行的研究更进一步,同时也为纳米技术在解决与新冠疫情相关问题中所起的作用提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b1d/7946821/593bdf476e30/gr1_lrg.jpg

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