Faculty of Nature and Life Sciences, Department of Organisms, University of Batna 2, Algeria.
Laboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, 05000, Batna, Algeria.
Eur J Pharmacol. 2021 Jan 15;891:173759. doi: 10.1016/j.ejphar.2020.173759. Epub 2020 Nov 27.
The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The lack of efficacious drugs and vaccines against this viral infection created a challenge for scientific researchers in order to find effective solutions. One of the promising therapeutic approaches is the search for bioactive molecules with few side effects that display antiviral properties in natural sources like medicinal plants and vegetables. Several computational and experimental studies indicated that flavonoids especially flavonols and their derivatives constitute effective viral enzyme inhibitors and possess interesting antiviral activities. In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CL), Papain Like protease (PL), Spike protein (S protein) and RNA-dependent RNA polymerase (RdRp), and also their ability to interact with the angiotensin-converting enzyme II (ACE2) receptor. The relationship between flavonol structures and their SARS-CoV-2 antiviral effects were discussed. On the other hand, the immunomodulatory, the anti-inflammatory and the antiviral effects of secondary metabolites from this class of flavonoids were reported. Also, their bioavailability limitations and toxicity were predicted.
新型冠状病毒爆发（COVID-19）是由严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2）引起的，这是实际存在的最大的全球公共卫生危机。针对这种病毒感染，缺乏有效的药物和疫苗，这给科学研究人员带来了挑战，需要寻找有效的解决方案。有希望的治疗方法之一是从药用植物和蔬菜等天然来源中寻找具有较少副作用且具有抗病毒特性的生物活性分子。几项计算和实验研究表明，类黄酮，尤其是黄酮醇及其衍生物，是有效的病毒酶抑制剂，具有有趣的抗病毒活性。在这种情况下，本研究综述了许多饮食类黄酮作为针对 SARS-CoV-2 酶和蛋白质（包括 3CL 蛋白酶、木瓜蛋白酶样蛋白酶（PL）、刺突蛋白（S 蛋白）和 RNA 依赖性 RNA 聚合酶（RdRp））的潜在抗病毒药物的功效，以及它们与血管紧张素转化酶 II（ACE2）受体相互作用的能力。讨论了类黄酮结构与它们对 SARS-CoV-2 的抗病毒作用之间的关系。另一方面，报道了这类类黄酮的次生代谢物的免疫调节、抗炎和抗病毒作用。还预测了它们的生物利用度限制和毒性。
