Yoshimura Aritada, Ohmori Takahiro, Itou Kokoro, Ishi Ryo, Matsumura Yuri, Wada Yuhei, Kishimoto Miori, Iwanaga Tomoko, Miura Naoki, Suzuki Kazuhiko, Fukushima Ryuji
Animal Medical Center, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Laboratory of Veterinary Imaging, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
J Vet Med Sci. 2021 May 9;83(5):780-783. doi: 10.1292/jvms.20-0409. Epub 2021 Mar 15.
In dogs, pancreatic acinar cell injury is thought to be caused by decreased pancreatic blood flow due to heart failure. In previous our report, it demonstrated that decreased heart function causes a significant decrease in pancreatic blood flow in heart failure dog model caused by rapid ventricular pacing (RVP). However, the types of histopathological changes remain unclear. We aimed to verify the types of histopathological changes occurring in the pancreatic tissue due to decreased heart function. After RVP for 4 weeks, atrophy of pancreatic acinar cells, characterized by a decrease in zymogen granules, was observed in all areas of the pancreas. In conclusion, the result of this study suggests that attention should be paid to ischemia/hypoperfusion injury in the pancreas.
在犬类中，胰腺腺泡细胞损伤被认为是由心力衰竭导致的胰腺血流减少所引起。在我们之前的报告中，证实了心功能下降会导致快速心室起搏（RVP）所致心力衰竭犬模型的胰腺血流显著减少。然而，组织病理学变化的类型仍不清楚。我们旨在验证因心功能下降而在胰腺组织中发生的组织病理学变化类型。在进行4周的RVP后，在胰腺的所有区域均观察到胰腺腺泡细胞萎缩，其特征为酶原颗粒减少。总之，本研究结果提示应关注胰腺的缺血/低灌注损伤。
