Zhang Chao, Ding RongFang, Sun YiCheng, Huo Si Tong, He Alina, Wen Chang, Chen HongHao, Du William W, Lai WeiNan, Wang Huijun
Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China.
Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China.
Mol Ther Nucleic Acids. 2021 Feb 4;23:1243-1257. doi: 10.1016/j.omtn.2021.01.032. eCollection 2021 Mar 5.
Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment. In this review, we focus on circRNAs involved in cancer tumorigenesis and metastasis. We present recently identified tumor-related circRNAs and discuss their functioning in tumor progression and metastasis. These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation of host genes, translation of circRNAs, and exosomal circRNAs. Additionally, the indirect functions of circRNAs that regulate epithelial-mesenchymal transition and autophagy are also discussed.
环状RNA（circRNAs）是一类内源性非编码RNA，已发现其可通过多种途径调控基因表达。转移仍然是癌症治疗中最大的障碍之一。在本综述中，我们聚焦于参与癌症发生和转移的环状RNA。我们介绍了最近鉴定出的与肿瘤相关的环状RNA，并讨论了它们在肿瘤进展和转移中的作用。这些环状RNA被分为不同的功能机制，包括微小RNA（miRNA）海绵作用、蛋白质结合、宿主基因调控、环状RNA翻译以及外泌体环状RNA。此外，还讨论了环状RNA调节上皮-间质转化和自噬的间接功能。
