Diniz Vinicius, Rath Gabriela, Rath Susanne, Rodrigues-Silva Caio, Guimarães José R, Cunha Davi G F
Department of Infrastructure and Environment, School of Civil Engineering, Architecture and Urban Design, University of Campinas, Campinas, Brazil.
Institute of Chemistry, University of Campinas, Campinas, Brazil.
Toxicol Rep. 2021 Feb 23;8:429-435. doi: 10.1016/j.toxrep.2021.02.020. eCollection 2021.
Ciprofloxacin (CIP) is an antimicrobial "pseudo-persistent" in aquatic ecosystems. Once dispersed in the water compartments, it can also affect the microalgae. Thus, the evaluation of its long-term ecotoxicological effects is necessary. CIP interactions with other pharmaceuticals are not well known. In this study, we investigated the toxic effects of CIP alone and combined with caffeine (CAF), using the modified Gompertz model parameters and the chlorophyll-a production of the microalga as endpoints, throughout a 16-day exposure assay. The exposure to CIP alone led to significant reductions of the growth rate and the cell density of the microalgae compared to control groups. The combination with CAF lowered the adverse effects of CIP to . However, as the toxicity is dynamic, our results indicated that the toxic effects in respect to the studied endpoints changed throughout the exposure period, reinforcing the need for longer-term ecotoxicity assessments.
环丙沙星（CIP）是一种在水生生态系统中具有“假持久性”的抗菌剂。一旦分散在水体中，它也会对微藻产生影响。因此，有必要评估其长期生态毒理学效应。CIP与其他药物的相互作用尚不明确。在本研究中，我们通过一项为期16天的暴露试验，以修正的冈珀茨模型参数和微藻叶绿素a产量为终点，研究了CIP单独作用以及与咖啡因（CAF）联合作用的毒性效应。与对照组相比，单独暴露于CIP会导致微藻的生长速率和细胞密度显著降低。与CAF联合使用降低了CIP的不利影响。然而，由于毒性是动态变化的，我们的结果表明，在所研究的终点方面，毒性效应在整个暴露期内都发生了变化，这进一步强调了进行长期生态毒性评估的必要性。
