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急性 COVID-19 感染后的血栓形成风险。

The risk of thrombosis after acute-COVID-19 infection.

机构信息

Department of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Cona, Ferrara, Italy.

Department of Specialistic Medicine, Division of Cardiology, Santa Maria della Misericordia Hospital, Rovigo General Hospital, Viale tre Martiri 140, Rovigo 45100, Italy.

出版信息

QJM. 2021 Nov 13;114(9):619-620. doi: 10.1093/qjmed/hcab054.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has been associated with coagulation dysfunction which predisposes patients to an increased risk of both venous and arterial thromboembolism, increasing the short-term morbidity and mortality. Current data evidenced that the rate of post-discharge thrombotic events in COVID-19 patients is lower compared to that observed during hospitalization. Rather than 'true thrombotic events', these complications seem more probably 'immunothrombosis' consequent to the recent infection. Unfortunately, the absence of data from randomized controlled trials, large prospective cohorts and ambulatory COVID-19 patients, left unresolved the question regarding the need of post-discharge thromboprophylaxis due to the absence of strong-level recommendations.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)与凝血功能障碍有关,这使患者更容易发生静脉和动脉血栓栓塞,增加了短期发病率和死亡率。目前的数据表明,与住院期间相比,COVID-19 患者出院后的血栓事件发生率较低。这些并发症似乎更可能是由于最近感染导致的“免疫性血栓形成”,而不是“真正的血栓事件”。不幸的是,由于缺乏随机对照试验、大型前瞻性队列和门诊 COVID-19 患者的数据,缺乏强有力的推荐意见,使得关于是否需要出院后进行血栓预防的问题仍未得到解决。

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