Ionova T I, Zinkovskaya A V, Mayevskaya E A, Nikitina T P, Porfirieva N M, Cheremushkina N V, Shaburov R I, Kucheryavyy Y A, Maev I V
Saint Petersburg State University Hospital.
Multinational Center for Quality of Life Research.
Ter Arkh. 2020 Dec 15;92(12):59-66. doi: 10.26442/00403660.2020.12.200434.
This study aimed to test the Russian version of GERD-HRQL in the focus group of patients with GERD, as well as to evaluate its psychometric properties reliability, validity and sensitivity.
The total of 57 patients with GERD (mean age 45.812.4 years, 72% women, 68% patients with not erosive reflux disease, 84% had esophageal manifestations of GERD) were enrolled into the study. All the patients filled out the Russian version of GERD-HRQL and generic quality of life questionnaire RAND SF-36 during the routine visit to the gastroenterologist. According to the results of testing of GERD-HRQL, it was clear and easy to complete for patients and reflected the main concerns specific for GERD patients. The most frequent and bothersome symptoms/problems which interfered with quality of life in GERD patients were heartburn (100% of patients) and bloating (84% of patients). During the validation procedure, the high reliability and validity of the Russian version of GERD-HRQL were demonstrated. It was shown that the tool was sensitive both to changes over time and to clinically determined differences in patients status.
The Total GERD-HRQL Score was significantly higher (worse quality of life) in the following groups: a) patients who had esophageal manifestations of GERB vs those without esophageal manifestations of GERB; b) patients with GERD complications vs those without GERD complications, c) patients with comorbidities of upper gastrointestinal tract vs without those comorbidities; d) patients with erosive esophagitis vs with non-erosive reflux disease (p0.05).
The developed Russian version of the GERD-HRQL questionnaire proved to have high psychometric properties and may be used in the Russian population of GERD patients both in research studies and in a real clinical practice.
本研究旨在对一组胃食管反流病（GERD）患者测试GERD-HRQL的俄语版本，并评估其心理测量特性，即信度、效度和敏感性。
共有57例GERD患者（平均年龄45.8±12.4岁，72%为女性，68%为非糜烂性反流病患者，84%有GERD的食管表现）纳入本研究。所有患者在常规就诊于胃肠病学家时填写GERD-HRQL俄语版本和一般生活质量问卷RAND SF-36。根据GERD-HRQL的测试结果，该问卷对患者来说清晰易填，反映了GERD患者特有的主要问题。GERD患者中干扰生活质量的最常见和最困扰的症状/问题是烧心（100%的患者）和腹胀（84%的患者）。在验证过程中，GERD-HRQL俄语版本显示出高信度和效度。结果表明，该工具对随时间的变化以及患者状态的临床确定差异均敏感。
以下几组患者的GERD-HRQL总分显著更高（生活质量更差）：a）有GERD食管表现的患者与无GERD食管表现的患者；b）有GERD并发症的患者与无GERD并发症的患者；c）有上消化道合并症的患者与无合并症的患者；d）糜烂性食管炎患者与非糜烂性反流病患者（p<0.05）。
所开发的GERD-HRQL问卷俄语版本被证明具有高心理测量特性，可用于俄罗斯GERD患者群体的研究和实际临床实践。
