Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
Mucosal Immunology and Biology Research Center, Harvard Medical School, Boston, Massachusetts, USA.
BMJ Open Gastroenterol. 2021 Mar;8(1). doi: 10.1136/bmjgast-2020-000587.
Inflammatory bowel diseases such as ulcerative colitis (UC) may be complicated by several extraintestinal manifestations. These involve joints, skin, eyes and less commonly lungs and heart. Myocarditis may result from the toxic effect of drugs (ie, mesalazine) commonly used for the treatment of UC or due to infections (eg, Coxsackieviruses, enteroviruses, adenovirus). Here, we report a case of a 26-year old man affected by UC and complicated by two episodes of myocarditis. Both episodes occurred during two severe exacerbations of UC. However, in both cases the aetiology of myocarditis remains uncertain being ascribable to extraintestinal manifestation, drug toxicity or both.
炎症性肠病,如溃疡性结肠炎(UC),可能会并发多种肠外表现。这些表现涉及关节、皮肤、眼睛,较少见的是肺部和心脏。心肌炎可能是由于治疗 UC 常用的药物(如美沙拉嗪)的毒性作用,也可能是由于感染(如柯萨奇病毒、肠道病毒、腺病毒)引起的。在这里,我们报告了一例 26 岁男性 UC 患者,并发了两次心肌炎。两次发作均发生在 UC 两次严重恶化期间。然而,在这两种情况下,心肌炎的病因仍不确定,可能归因于肠外表现、药物毒性或两者兼而有之。