Emergency and Critical Care Intern, Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK.
American, European Board of Veterinary Specialisation & Royal College of Veterinary Surgeons Recognised Specialist in Emergency & Critical Care, National Emergency and Critical Care (ECC) Lead, Vets-Now, Referral Clinician in ECC, Vets-Now Glasgow, G3 7DA, UK.
J Small Anim Pract. 2021 May;62(5):373-378. doi: 10.1111/jsap.13281. Epub 2021 Mar 15.
To investigate the prevalence of Clostridium perfringens alpha toxin encoding gene and C. perfringens enterotoxin encoding gene in dogs with acute haemorrhagic diarrhoea syndrome.
Retrospective study looking at the prevalence of C. perfringens alpha toxin and C. perfringens enterotoxin in the faeces of three groups of dogs - those with acute haemorrhagic diarrhoea syndrome (n = 16), those with haemorrhagic diarrhoea from another cause (n = 17) and those without haemorrhagic diarrhoea (n = 10). Correlation between the presence of C. perfringens alpha toxin and/or C. perfringens enterotoxin and Acute Patient Physiological and Laboratory Evaluation scores, acute haemorrhagic diarrhoea index scores and length of hospitalisation in dogs with acute haemorrhagic diarrhoea syndrome was assessed.
Prevalence of C. perfringens alpha toxin was not higher in dogs with acute haemorrhagic diarrhoea syndrome (43.75%) than dogs with haemorrhagic diarrhoea from another cause (58.82%) (difference in prevalence 15.07%; 95% CI -37% to 32%) or in dogs without haemorrhagic diarrhoea (60%) (difference in prevalence 16.25%; 95% CI -4% to 36%). Dogs with acute haemorrhagic diarrhoea syndrome did not have a significantly higher prevalence of C. perfringens enterotoxin (18.75%) compared to dogs without haemorrhagic diarrhoea (11.76%) (difference in prevalence 6.99%; 95% CI -18% to 32%). Prevalence of C. perfringens enterotoxin was similar in dogs with acute haemorrhagic diarrhoea syndrome and dogs without haemorrhagic diarrhoea (20%) (difference in prevalence 1.25% 95% CI -33% to 30%). The presence of C. perfringens alpha toxin did not correlate with increased Acute Patient Physiological and Laboratory Evaluation scores, acute haemorrhagic diarrhoea index scores or length of hospitalisation in dogs with acute haemorrhagic diarrhoea syndrome.
This study does not demonstrate increased prevalence of C. perfringens alpha toxin or C. perfringens enterotoxin in dogs with acute haemorrhagic diarrhoea syndrome compared to dogs with haemorrhagic diarrhoea from another cause or dogs without haemorrhagic diarrhoea.
研究犬急性出血性腹泻综合征中产气荚膜梭菌α毒素编码基因和产气荚膜梭菌肠毒素编码基因的流行情况。
回顾性研究观察了三组犬的产气荚膜梭菌α毒素和产气荚膜梭菌肠毒素的流行情况-急性出血性腹泻综合征组（n=16）、其他原因引起的出血性腹泻组（n=17）和无出血性腹泻组（n=10）。评估了急性出血性腹泻综合征犬中存在产气荚膜梭菌α毒素和/或产气荚膜梭菌肠毒素与急性患者生理和实验室评估评分、急性出血性腹泻指数评分和住院时间的相关性。
急性出血性腹泻综合征犬中产气荚膜梭菌α毒素的流行率（43.75%）并不高于其他原因引起的出血性腹泻犬（58.82%）（流行率差异 15.07%；95%CI-37%至 32%）或无出血性腹泻犬（60%）（流行率差异 16.25%；95%CI-4%至 36%）。与无出血性腹泻犬（11.76%）相比，急性出血性腹泻综合征犬中产气荚膜梭菌肠毒素的流行率（18.75%）并没有显著升高（流行率差异 6.99%；95%CI-18%至 32%）。急性出血性腹泻综合征犬和无出血性腹泻犬中产气荚膜梭菌肠毒素的流行率相似（20%）（流行率差异 1.25%，95%CI-33%至 30%）。在急性出血性腹泻综合征犬中，产气荚膜梭菌α毒素的存在与增加的急性患者生理和实验室评估评分、急性出血性腹泻指数评分或住院时间无关。
本研究未证明与其他原因引起的出血性腹泻或无出血性腹泻犬相比，急性出血性腹泻综合征犬中产气荚膜梭菌α毒素或产气荚膜梭菌肠毒素的流行率增加。
