Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
Bull Exp Biol Med. 2021 Feb;170(4):401-404. doi: 10.1007/s10517-021-05075-w. Epub 2021 Mar 16.
We analyzed the behavior and peripheral blood T- and B-cell subpopulations in mice overexpressing the mutant form of human α-synuclein (A53T) in comparison with mice of the wild type (WT) parent C57BL/6J strain. Behavioral phenotype and the content of various cell subpopulations of A53T mice depended on animal age. Young (2-month-old mice) were characterized by low emotionality and the most pronounced changes in cell subpopulation composition (an increase in CD3T cells and CD4T helper cells, a decrease in CD19B cells along with unchanged content of CD3CD4CD25T-regulatory cells and CD19CD25B-regulatory cells). In old A53T mice (10-month-old), movement impairments appeared and increased numbers of CD4T helper cells and CD3CD4CD25T-regulatory cells were revealed.
我们分析了在过表达人α-突触核蛋白（A53T）突变体的小鼠（与野生型（WT）C57BL/6J 品系的小鼠相比）中的行为和外周血 T 细胞和 B 细胞亚群。A53T 小鼠的行为表型和各种细胞亚群的含量取决于动物的年龄。年轻（2 月龄）的小鼠表现出低情绪性和细胞亚群组成的最明显变化（CD3T 细胞和 CD4T 辅助细胞增加，CD19B 细胞减少，而 CD3CD4CD25T 调节细胞和 CD19CD25B 调节细胞的含量不变）。在年老的 A53T 小鼠（10 月龄）中，运动障碍出现，CD4T 辅助细胞和 CD3CD4CD25T 调节细胞的数量增加。
