Faculty of Pharmacy, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City, Vietnam.
Vietnam Sports Hospital, Ministry of Culture, Sports and Tourism, Hanoi, Vietnam.
Adv Exp Med Biol. 2021;1286:183-198. doi: 10.1007/978-3-030-55035-6_13.
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline. Existing drugs only suppress symptoms or delay further deterioration but do not address the cause of the disease. In spite of screening numerous drug candidates against various molecular targets of AD, only a few candidates, such as acetylcholinesterase inhibitors, are currently utilized as an effective clinical therapy. Currently, nano-based therapies can make a difference, providing new therapeutic options by helping drugs to cross the blood-brain barrier and enter the brain more effectively. The main aim of this review was to highlight advances in research on the development of nano-based therapeutics for improved treatment of AD.
阿尔茨海默病（AD）是一种神经退行性疾病，其中脑细胞的死亡会导致记忆力减退和认知能力下降。现有的药物只能抑制症状或延缓进一步恶化，但不能解决疾病的根本原因。尽管针对 AD 的各种分子靶点筛选了众多药物候选物，但目前只有少数候选物（如乙酰胆碱酯酶抑制剂）被用作有效的临床治疗方法。目前，基于纳米技术的疗法可以发挥作用，通过帮助药物更有效地穿过血脑屏障并进入大脑，提供新的治疗选择。本综述的主要目的是强调在开发基于纳米技术的治疗方法以改善 AD 治疗方面的研究进展。
