Bruinsma Robijn F, Wuite Gijs J L, Roos Wouter H
Department of Physics and Astronomy, University of California, Los Angeles, California, USA.
Fysica van levende systemen, Vrije Universiteit, Amsterdam, the Netherlands.
Nat Rev Phys. 2021;3(2):76-91. doi: 10.1038/s42254-020-00267-1. Epub 2021 Jan 12.
Viral capsids are often regarded as inert structural units, but in actuality they display fascinating dynamics during different stages of their life cycle. With the advent of single-particle approaches and high-resolution techniques, it is now possible to scrutinize viral dynamics during and after their assembly and during the subsequent development pathway into infectious viruses. In this Review, the focus is on the dynamical properties of viruses, the different physical virology techniques that are being used to study them, and the physical concepts that have been developed to describe viral dynamics.
病毒衣壳通常被视为无活性的结构单元，但实际上它们在生命周期的不同阶段展现出迷人的动态变化。随着单颗粒方法和高分辨率技术的出现，现在有可能仔细研究病毒在组装过程中及之后，以及在随后发展为感染性病毒的途径中的动态变化。在本综述中，重点关注病毒的动力学特性、用于研究它们的不同物理病毒学技术，以及为描述病毒动力学而发展起来的物理概念。
