Cancer & Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, 66177-13446, Iran.
Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, 66177-13446, Iran.
Future Oncol. 2021 May;17(15):1943-1961. doi: 10.2217/fon-2020-1103. Epub 2021 Mar 17.
Tumors are equipped with a highly complex machinery of interrelated events so as to adapt to hazardous conditions, preserve a growing cell mass and thrive at the site of metastasis. Tumor cells display metastatic propensity toward specific organs where the stromal milieu is appropriate for their further colonization. Effective colonization relies on the plasticity of tumor cells in adapting to the conditions of the new area by reshaping their epigenetic landscape. Breast cancer cells, for instance, are able to adopt brain-like or epithelial/osteoid features in order to pursue effective metastasis into brain and bone, respectively. The aim of this review is to discuss recent insights into organ tropism in tumor metastasis, outlining potential strategies to address this driver of tumor aggressiveness.
肿瘤配备了高度复杂的相互关联事件的机制，以适应危险的条件，保持不断增长的细胞质量，并在转移部位茁壮成长。肿瘤细胞具有向特定器官转移的倾向，这些器官的基质环境适合它们进一步定植。有效的定植依赖于肿瘤细胞通过重塑其表观遗传景观来适应新区域条件的可塑性。例如，乳腺癌细胞能够采用类似于大脑的或上皮/骨样特征，以便分别有效地转移到大脑和骨骼中。本文的目的是讨论肿瘤转移中器官趋向性的最新见解，概述解决这种肿瘤侵袭性驱动因素的潜在策略。
