Basov Alexandr, Fedulova Liliya, Vasilevskaya Ekaterina, Trofimova Ekaterina, Murashova Nataliya, Dzhimak Stepan
Kuban State Medical University, Mitrophana Sedina Street, Krasnodar 350063, Russian Federation.
Kuban State University, Stavropolskaya Street, 149, Krasnodar 350040, Russian Federation.
Saudi J Biol Sci. 2021 Mar;28(3):1826-1834. doi: 10.1016/j.sjbs.2020.12.028. Epub 2020 Dec 21.
Influence of a new protein-peptide complex on promoting skin wound healing in male mice was studied. Protein-peptide complex, extracted from immune organs, was percutaneously administered using two methods: by lecithin gel-like liquid crystals and by liquid microemulsion. On the fifth day, wound closure in mice with a linear wound model become faster in group (less 2 days comparison to other ones), which was treated with lecithin liquid crystals carrying the protein-peptide complex. This promoting healing can be caused by resorption of bioactive high-molecular compounds the animal skin. In mice with the linear wound model, the tensile strength of the scars were respectively higher both in mice, treated using lecithin liquid crystals with protein-peptide complex, and in mice, treated using microemulsion containing protein-peptide complex, by 215.4% and 161.5% relative to the animals, which did not receive bioactive substances for wound treatment. It was associated with the regeneratory effects of tissue- and species-specific protein-peptide complexes, including α-thymosin (C3VVV8_PIG, / 3802.8) and other factors, which were described as parts of the new extracted complex. This reveals that percutaneous administration of the complex reliably activates local regenerative processes in animals.
研究了一种新型蛋白质 - 肽复合物对促进雄性小鼠皮肤伤口愈合的影响。从免疫器官中提取的蛋白质 - 肽复合物采用两种方法经皮给药：通过卵磷脂凝胶状液晶和微乳剂。在第五天，采用携带蛋白质 - 肽复合物的卵磷脂液晶处理的线性伤口模型小鼠组的伤口闭合速度更快（与其他组相比少2天）。这种促进愈合可能是由于动物皮肤对生物活性高分子化合物的吸收所致。在采用线性伤口模型的小鼠中，使用含蛋白质 - 肽复合物的卵磷脂液晶处理的小鼠和使用含蛋白质 - 肽复合物的微乳剂处理的小鼠，其疤痕的抗张强度相对于未接受用于伤口治疗的生物活性物质的动物分别高出215.4%和161.5%。这与组织和物种特异性蛋白质 - 肽复合物的再生作用有关，包括α - 胸腺素（C3VVV8_PIG，/ 3802.8）和其他被描述为新提取复合物组成部分的因子。这表明经皮给予该复合物能可靠地激活动物体内的局部再生过程。
