Akhtar Naveed, Fiaz Khan Muhammad, Tabassum Sadia, Zahran Eman
Department of Zoology, Hazara University Mansehra, Pakistan.
Department of Internal Medicine, Infectious and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Egypt.
Saudi J Biol Sci. 2021 Mar;28(3):1999-2003. doi: 10.1016/j.sjbs.2021.01.001. Epub 2021 Jan 7.
This study was conducted to evaluate the adverse effects of atrazine on hematology, biochemistry and genotoxicity of snow trout (). Almost all treated groups presented considerably ( < 0.05) lesser values of hematocrit, hemoglobin, WBC, RBC, MCH, MCHC, monocytes and lymphocytes while significantly higher values of HCT and platelets are observed. A Significant decrease is observed in sodium, calcium, potassium, phosphorous, triglycerides, creatinine, urea, and total protein contents whereas, a significant increase is observed in cholesterol and glucose level. Significant ( < 0.05) alterations are observed in enzyme activities of all treated groups. DNA damage was observed at the concentrations (2-4 ppm). Results showed that Comet assay is reliable for evaluating the toxicity and is helpful in environmental monitoring programs.
本研究旨在评估莠去津对雪鲑血液学、生物化学和遗传毒性的不良影响。几乎所有处理组的血细胞比容、血红蛋白、白细胞、红细胞、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度、单核细胞和淋巴细胞的值均显著降低（P<0.05），而血细胞比容和血小板的值显著升高。观察到钠、钙、钾、磷、甘油三酯、肌酐、尿素和总蛋白含量显著降低，而胆固醇和葡萄糖水平显著升高。所有处理组的酶活性均有显著（P<0.05）变化。在浓度为2-4 ppm时观察到DNA损伤。结果表明，彗星试验在评估毒性方面可靠，有助于环境监测计划。
