Universidade de Passo Fundo, Faculdade de Agronomia e Medicina Veterinária, Campus I, Bairro São José, BR 282, km 171, 99052-900 Passo Fundo, RS, Brazil.
Fish Shellfish Immunol. 2012 Oct;33(4):1055-9. doi: 10.1016/j.fsi.2012.08.006. Epub 2012 Aug 17.
The impact of agrichemicals on aquatic vertebrate species has been a matter of increasing concern to researchers and environmentalist. In the present study, we evaluated the effects of a sublethal concentration of atrazine (10% of the LC(50-96 h)), a world-wide used herbicide, on the innate immune system of silver catfish (Rhamdia quelen). A significant reduction on phagocytic index, bacteria agglutination and bactericidal activity of the serum, serum lysozyme and total serum peroxidase activity was observed in fish exposed to atrazine for 24 h. After 10 days exposure to atrazine, only bactericidal activity of the serum, bacteria agglutination and total serum peroxidase activity were significantly reduced. Atrazine had no effect on the natural complement hemolytic activity. Our results demonstrate that atrazine decreases the innate immune response of fingerlings, which might increase its susceptibility to opportunistic pathogens.
农用化学品对水生脊椎动物物种的影响一直是研究人员和环保主义者日益关注的问题。在本研究中，我们评估了一种世界范围内广泛使用的除草剂莠去津（LC（50-96h）的 10%）对银鲶（Rhamdia quelen）先天免疫系统的影响。暴露于莠去津 24 小时后，鱼的吞噬指数、血清中的细菌凝集和杀菌活性、血清溶菌酶和总血清过氧化物酶活性显著降低。暴露于莠去津 10 天后，仅血清杀菌活性、血清中的细菌凝集和总血清过氧化物酶活性显著降低。莠去津对天然补体溶血活性没有影响。我们的结果表明，莠去津降低了鱼苗的先天免疫反应，这可能使其更容易受到机会性病原体的侵害。
