Chen Lili, Qian Xinle, Wang Zhongqi, Zhou Xiqiu
Department of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China.
Oncol Lett. 2021 Apr;21(4):302. doi: 10.3892/ol.2021.12563. Epub 2021 Feb 17.
Long non-coding RNA (lncRNA) is a new type of non-coding RNA that has an important regulatory influence on several human diseases, including cancer metastasis. HOX antisense intergenic RNA (HOTAIR), a newly discovered lncRNA, has an important effect on tumour proliferation, migration and metastasis. HOTAIR regulates cell proliferation, changes gene expression, and promotes tumour cell invasion and migration. However, its molecular mechanism of action remains unknown. The present review summarizes the molecular mechanism and role of HOTAIR in tumour invasion and metastasis, discusses the association between HOTAIR and tumour metastasis through different pathways, such as the transforming growth factor β, Wnt/β-catenin, PI3K/AKT/MAPK and vascular endothelial growth factor pathways, emphasizes the function of HOTAIR in human malignant tumour metastasis and provides a foundation for its application in the diagnosis, prognosis and medical treatment of various tumours.
长链非编码RNA（lncRNA）是一种新型的非编码RNA，对包括癌症转移在内的多种人类疾病具有重要的调节作用。HOX反义基因间RNA（HOTAIR）是一种新发现的lncRNA，对肿瘤增殖、迁移和转移具有重要影响。HOTAIR调节细胞增殖，改变基因表达，并促进肿瘤细胞的侵袭和迁移。然而，其分子作用机制尚不清楚。本综述总结了HOTAIR在肿瘤侵袭和转移中的分子机制及作用，探讨了HOTAIR通过不同途径（如转化生长因子β、Wnt/β-连环蛋白、PI3K/AKT/MAPK和血管内皮生长因子途径）与肿瘤转移之间的关联，强调了HOTAIR在人类恶性肿瘤转移中的作用，并为其在各种肿瘤的诊断、预后和治疗中的应用提供了依据。
