两种富含棕榈酸或硬脂酸的连续混合餐对健康体重和超重男性及绝经后女性 8 小时餐后血脂和血糖的影响：一项随机对照试验。

Effects of two consecutive mixed meals high in palmitic acid or stearic acid on 8-h postprandial lipemia and glycemia in healthy-weight and overweight men and postmenopausal women: a randomized controlled trial.

机构信息

Department of Nutrition and Movement Sciences, NUTRIM (School of Nutrition and Translational Research in Metabolism), Maastricht University Medical Center, Maastricht, The Netherlands.

Unilever Research and Development, Wageningen, The Netherlands.

出版信息

Eur J Nutr. 2021 Oct;60(7):3659-3667. doi: 10.1007/s00394-021-02530-2. Epub 2021 Mar 17.

PURPOSE

Palmitic and stearic acids have different effects on fasting serum lipoproteins. However, the effects on postprandial lipemia and glycemia are less clear. Also, the effects of a second meal may differ from those of the first meal. Therefore, we studied the effects of two consecutive mixed meals high in palmitic acid- or stearic acid-rich fat blends on postprandial lipemia and glycemia.

METHODS

In a randomized, crossover study, 32 participants followed 4-week diets rich in palmitic or stearic acids, At the end of each dietary period, participants consumed two consecutive meals each containing ± 50 g of the corresponding fat blend.

RESULTS

Postprandial concentrations of triacylglycerol (diet-effect: - 0.18 mmol/L; p = 0.001) and apolipoprotein B48 (diet-effect: - 0.68 mg/L; p = 0.002) were lower after stearic-acid than after palmitic-acid intake. Consequently, total (iAUC) and first meal (iAUC) responses were lower after stearic-acid intake (p ≤ 0.01). Second meal responses (iAUC) were not different. Postprandial changes between the diets in non-esterified fatty acids (NEFA) and C-peptide differed significantly over time (p < 0.001 and p = 0.020 for diet*time effects, respectively), while those for glucose and insulin did not. The dAUC, dAUC, and dAUC for NEFA were larger after stearic-acid intake (p ≤ 0.05). No differences were observed in the iAUCs of C-peptide, glucose, and insulin. However, second meal responses for glucose and insulin (iAUC tended to be lower after stearic-acid intake (p < 0.10).

CONCLUSION

Consumption of the stearic acid-rich meals lowered postprandial lipemia as compared with palmitic acid. After the second stearic acid-rich meal, concentrations of C-peptide peaked earlier and those of NEFA decreased more. Clinical trial registry This trial was registered at clinicaltrials.gov as NCT02835651 on July 18, 2016.

目的

棕榈酸和硬脂酸对空腹血清脂蛋白有不同的影响。然而，对餐后脂血症和血糖的影响则不太清楚。此外，第二餐的影响可能与第一餐不同。因此，我们研究了连续两次富含棕榈酸或硬脂酸的混合餐对餐后脂血症和血糖的影响。

方法

在一项随机交叉研究中，32 名参与者遵循富含棕榈酸或硬脂酸的饮食 4 周。在每个饮食期结束时，参与者分别食用两次连续的餐食，每次餐食均含有 50g 相应的脂肪混合物。

结果

与棕榈酸相比，硬脂酸摄入后三酰甘油（饮食效应：-0.18mmol/L；p=0.001）和载脂蛋白 B48（饮食效应：-0.68mg/L；p=0.002）的餐后浓度较低。因此，总（iAUC）和第一餐（iAUC）的反应在硬脂酸摄入后较低（p≤0.01）。第二餐的反应（iAUC）则没有差异。非酯化脂肪酸（NEFA）和 C 肽的餐后变化在不同时间的饮食之间存在显著差异（饮食*时间效应的 p 值分别<0.001 和 p=0.020），而葡萄糖和胰岛素则没有。与硬脂酸摄入相比，NEFA 的 dAUC、dAUC 和 dAUC 更大（p≤0.05）。C 肽、葡萄糖和胰岛素的 iAUC 无差异。然而，第二餐的葡萄糖和胰岛素（iAUC 有倾向于在硬脂酸摄入后较低（p<0.10）。