钙镁摄入量比值与非酒精性脂肪性肝病发生的关系：病例对照研究。
Calcium to magnesium intake ratio and non-alcoholic fatty liver disease development: a case-control study.
机构信息
Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, ShahidBeheshti University of Medical Sciences, 19395 - 4741, No 7, West Arghavan St., Farahzadi Blvd, 1981619573, Tehran, Iran.
出版信息
BMC Endocr Disord. 2021 Mar 18;21(1):51. doi: 10.1186/s12902-021-00721-w.
BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Adoption of sedentary life style and westernized diet are shown to be associated with development of NAFLD. Since previous studies suggested that calcium (Ca) to magnesium (Mg) ratio intake is associated with some chronic diseases including dyslipidemia and insulin resistance, we designed this study to find any possible association between this ratio and NAFLD development.
METHODS
The NAFLD was diagnosed using Fibroscan according to a CAP cut-off value of 263 dB/m. Dietary intakes of one hundred and ninety-six patients with incident NAFLD diagnosis, and eight hundred and three controls without NAFLD were assessed using a valid food frequency questionnaire (FFQ). Dietary nutrients were calculated using Nutritionist IV software.
RESULTS
Age of the study population (57 % female) was 43.2 ± 14.1 years. In addition, energy-adjusted daily calcium to magnesium intake ratio was 2.34 ± 0.57 and 2.73 ± 0.69 for control and case groups, respectively. In the multivariable-adjusted model, after adjustment for potential confounding variables; including, age, gender, BMI, alcohol consumption, smoking, diabetes, physical activity, energy, dietary fiber, carbohydrate, fat, and protein intakes, participants in the third (Q3) and fourth (Q4) quartile of Ca/Mg ratio intake had a greater development of incidental NAFLD compared to the lowest quartile (Q1) [(OR = 2.86; 95 % CI: 1.20-6.81), (P-value = 0.017) and (OR = 5.97; 95 % CI: 2.54-14.01), (P-value < 0.001) for Q3 and Q4 compared to the Q1, respectively]. Moreover, energy-adjusted Ca to Mg intake ratio was positively correlated with plasma level of ALT (r = 0.18; P = 0.01); contrarily, it had no correlation with plasma levels of AST.
CONCLUSIONS
The current study revealed that higher dietary Ca to Mg intake ratio is associated with a greater development of NAFLD. Further interventional studies are needed to confirm the causal relationship of the Ca/Mg ratio intake and development of NAFLD.
背景
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病。研究表明，久坐的生活方式和西式饮食与 NAFLD 的发生发展有关。由于先前的研究表明钙（Ca）与镁（Mg）的比值摄入与一些慢性疾病有关，包括血脂异常和胰岛素抵抗，因此我们设计了这项研究，以发现这种比值与 NAFLD 发展之间的任何可能联系。
方法
使用 Fibroscan 根据 CAP 截断值 263 dB/m 诊断 NAFLD。使用有效的食物频率问卷（FFQ）评估 196 例新发 NAFLD 患者和 803 例无 NAFLD 对照组的饮食摄入量。使用营养师 IV 软件计算饮食营养素。
结果
研究人群的年龄（57%为女性）为 43.2±14.1 岁。此外，对照组和病例组的能量校正后钙镁日摄入量比值分别为 2.34±0.57 和 2.73±0.69。在多变量调整模型中，调整潜在混杂变量后，包括年龄、性别、BMI、饮酒、吸烟、糖尿病、体力活动、能量、膳食纤维、碳水化合物、脂肪和蛋白质摄入量，第 3（Q3）和第 4（Q4）四分位组的参与者与最低四分位组（Q1）相比，偶然发生的 NAFLD 发展更大[比值比（OR）=2.86；95%置信区间（CI）：1.20-6.81），（P 值=0.017）和（OR=5.97；95%CI：2.54-14.01），（P 值<0.001）与 Q1 相比，Q3 和 Q4]。此外，能量校正后的钙与镁摄入量比值与血浆丙氨酸转氨酶（ALT）水平呈正相关（r=0.18；P=0.01）；相反，它与血浆天冬氨酸转氨酶（AST）水平无相关性。
结论
本研究表明，较高的饮食钙与镁摄入量比值与 NAFLD 的发生发展密切相关。需要进一步的干预研究来证实钙/镁比值摄入与 NAFLD 发展之间的因果关系。
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