Asbaghi Omid, Emamat Hadi, Kelishadi Mahnaz Rezaei, Hekmatdoost Azita
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran.
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
Clin Nutr Res. 2020 Jul 27;9(3):195-204. doi: 10.7762/cnr.2020.9.3.195. eCollection 2020 Jul.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. Nuts are nutrient- and calorie-dense foods with several health-promoting compounds. In this case-control study, we investigated the association between nut intake and NAFLD risk. Hundred ninety-six subjects with NAFLD and eight hundred three controls were recruited. The participants' dietary intakes were assessed by a valid and reliable semi-quantitative food frequency questionnaire (FFQ). Participants were categorized according to deciles of daily nuts intake. Multivariable logistic regression models were used with NAFLD as the dependent and deciles of daily nuts intake as an independent variables. Range of age was 18 to 75 years. Forty three percent of participants were male. Range of nuts intake was between 0 to 90.90 g/day. In model 3, after adjusting for potential confounding variables including, age, sex, BMI, alcohol consumption, smoking, diabetes and physical activity, the relation between daily nuts intake and risk of NAFLD was positive and significant in the deciles 9 and 10 compared to the lowest decile (odds ratio [OR], 3.22; 95% confidence interval [CI], 1.04-7.49; p = 0.039 and OR, 3.03; 95% CI, 1.03-8.90; p = 0.046, respectively). However, in the final model after additional adjusting for energy intake, no significant association was found. According to the findings, there is not any significant relationship between nuts intake and NAFLD risk; while higher intake of nuts is related to the higher risk of NAFLD mediated by energy intake.
非酒精性脂肪性肝病（NAFLD）是慢性肝病最常见的病因。坚果是营养丰富且热量密集的食物，含有多种促进健康的化合物。在这项病例对照研究中，我们调查了坚果摄入量与NAFLD风险之间的关联。招募了196名NAFLD患者和803名对照者。通过有效且可靠的半定量食物频率问卷（FFQ）评估参与者的饮食摄入量。参与者根据每日坚果摄入量的十分位数进行分类。使用多变量逻辑回归模型，将NAFLD作为因变量，每日坚果摄入量的十分位数作为自变量。年龄范围为18至75岁。43%的参与者为男性。坚果摄入量范围为0至90.90克/天。在模型3中，在调整了包括年龄、性别、BMI、饮酒、吸烟、糖尿病和身体活动等潜在混杂变量后，与最低十分位数相比，每日坚果摄入量与NAFLD风险之间的关系在第9和第10十分位数中呈正相关且具有统计学意义（优势比[OR]，3.22；95%置信区间[CI]，1.04 - 7.49；p = 0.039；OR，3.03；95%CI，1.03 - 8.90；p = 0.046）。然而，在进一步调整能量摄入量后的最终模型中，未发现显著关联。根据研究结果，坚果摄入量与NAFLD风险之间没有任何显著关系；而较高的坚果摄入量与能量摄入介导的较高NAFLD风险相关。
