Sultana Shirin, Zarreen Fauzia, Chakraborty Supriya
Molecular Virology Laboratory, School of Life Science, Jawaharlal Nehru University, New Delhi, 110067, India.
Molecular Virology Laboratory, School of Life Science, Jawaharlal Nehru University, New Delhi, 110067, India.
Virus Res. 2021 May;297:198395. doi: 10.1016/j.virusres.2021.198395. Epub 2021 Mar 15.
Nucleosomes are assembled or disassembled with the aid of histone chaperones in a cell. Viruses can exist either as minichromosomes/episomes or can integrate into the host genome and in both the cases the viral proteins interact and manipulate the cellular nucleosome assembly machinery to ensure their survival and propagation. Recent studies have provided insight into the mechanism and role of histone chaperones in nucleosome assembly and disassembly on the virus genome. Further, the interactions between viral proteins and histone chaperones have been implicated in the integration of the virus genome into the host genome. This review highlights the recent progress and future challenges in understanding the role of histone chaperones in viruses with DNA or RNA genome and their role in governing viral pathogenesis.
在细胞中，核小体借助组蛋白伴侣进行组装或拆卸。病毒既可以以微型染色体/附加体的形式存在，也可以整合到宿主基因组中，在这两种情况下，病毒蛋白都会与细胞内核小体组装机制相互作用并对其进行操控，以确保自身的存活和传播。最近的研究深入了解了组蛋白伴侣在病毒基因组上核小体组装和拆卸过程中的机制及作用。此外，病毒蛋白与组蛋白伴侣之间的相互作用与病毒基因组整合到宿主基因组的过程有关。本综述重点介绍了在理解组蛋白伴侣在具有DNA或RNA基因组的病毒中的作用及其在控制病毒发病机制方面的作用方面的最新进展和未来挑战。
