组蛋白伴侣在核小体组装和人类疾病中的作用。
Histone chaperones in nucleosome assembly and human disease.
机构信息
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
出版信息
Nat Struct Mol Biol. 2013 Jan;20(1):14-22. doi: 10.1038/nsmb.2461.
Abstract
Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.
摘要
DNA 复制、DNA 修复和基因转录后核小体的组装对于维持基因组稳定性和表观遗传信息至关重要。核小体的组装是通过复制偶联或复制独立途径，在组蛋白伴侣蛋白的帮助下完成的。这些不同的核小体组装途径如何被调节仍然相对不清楚。最近的研究提供了对组蛋白伴侣在调节核小体组装中的作用和机制的深入了解。参与核小体组装的因素的改变或突变也与癌症和其他人类疾病有关。本综述强调了该领域的最新进展，并概述了未来的挑战。
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1
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Nat Struct Mol Biol. 2013 Jan;20(1):29-35. doi: 10.1038/nsmb.2446. Epub 2012 Nov 25.
2
Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX.变体组蛋白 H3.3-H4 异二聚体与它的伴侣蛋白 DAXX 的复合物结构。
Nat Struct Mol Biol. 2012 Dec;19(12):1287-92. doi: 10.1038/nsmb.2439. Epub 2012 Nov 11.
3
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Nature. 2012 Nov 22;491(7425):560-5. doi: 10.1038/nature11608. Epub 2012 Oct 17.
4
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Nucleic Acids Res. 2012 Nov 1;40(20):10139-49. doi: 10.1093/nar/gks812. Epub 2012 Aug 31.
5
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6
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