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紫外线 C 照射在灭活 SARS-CoV-2 复制方面非常有效。

UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication.

机构信息

Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy.

Italian National Institute for Astrophysics (INAF)-Brera Astronomical Observatory, Merate, Italy.

出版信息

Sci Rep. 2021 Mar 18;11(1):6260. doi: 10.1038/s41598-021-85425-w.

DOI:10.1038/s41598-021-85425-w
PMID:33737536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7973506/
Abstract

The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm. These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.

摘要

实验评估了不同光照剂量和病毒浓度（1000、5、0.05 MOI）对 SARS-CoV-2 的潜在病毒杀灭效果。在与 SARS-CoV-2 感染中观察到的病毒密度相当的情况下，只需 3.7 mJ/cm 的 UV-C 剂量即可实现超过 3 个对数的失活，而没有任何病毒复制的迹象。此外，在所有病毒浓度下，观察到 16.9 mJ/cm 时完全失活。这些结果可以解释 COVID-19 的流行病学趋势，对于开发新的消毒方法来控制 SARS-CoV-2 感染非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/b09549a1a6f4/41598_2021_85425_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/1edd201fc5da/41598_2021_85425_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/9f18ab64f07d/41598_2021_85425_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/d9cc9bca2013/41598_2021_85425_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/f63889c2f4d1/41598_2021_85425_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/b09549a1a6f4/41598_2021_85425_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/1edd201fc5da/41598_2021_85425_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/9f18ab64f07d/41598_2021_85425_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/d9cc9bca2013/41598_2021_85425_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/f63889c2f4d1/41598_2021_85425_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbd7/7973506/b09549a1a6f4/41598_2021_85425_Fig5_HTML.jpg

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