Sprugnoli Giulia, Golby Alexandra J, Santarnecchi Emiliano
Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Radiology Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Neurooncol Adv. 2021 Feb 4;3(1):vdab018. doi: 10.1093/noajnl/vdab018. eCollection 2021 Jan-Dec.
The newly discovered functional integration of glioma cells into brain networks in mouse models provides groundbreaking insight into glioma aggressiveness and resistance to treatments, also suggesting novel potential therapeutic avenues and targets. In the context of such neuron-to-glioma communication, noninvasive brain modulation techniques traditionally applied to modulate neuronal function in neurological and psychiatric diseases (eg, increase/decrease cortical excitability and plasticity) could now be tested in patients with brain tumors to suppress glioma's activity and its pathological crosstalk with healthy brain tissue.
在小鼠模型中，新发现的胶质瘤细胞与脑网络的功能整合为胶质瘤的侵袭性和治疗抗性提供了开创性的见解，也提示了新的潜在治疗途径和靶点。在这种神经元与胶质瘤的交流背景下，传统上用于调节神经和精神疾病中神经元功能（例如，增加/降低皮质兴奋性和可塑性）的非侵入性脑调制技术，现在可以在脑肿瘤患者中进行测试，以抑制胶质瘤的活性及其与健康脑组织的病理串扰。
