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丙型肝炎治疗标准:直接作用抗病毒治疗问世以来良好实践的回顾。

Hepatitis C standards of care: A review of good practices since the advent of direct-acting antiviral therapy.

机构信息

Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.

Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.

出版信息

Clin Res Hepatol Gastroenterol. 2021 Mar;45(2):101564. doi: 10.1016/j.clinre.2020.11.001. Epub 2021 Mar 16.

Abstract

Significant steps must be taken to reduce the global incidence and prevalence of hepatitis C virus (HCV) and mortality from HCV infection to achieve the WHO goal of eliminating viral hepatitis as a public health threat by 2030. Proper epidemiological surveillance of the full continuum of care is essential for monitoring progress and identifying gaps that need to be addressed. The tools required for elimination have largely been established, and the issue at hand is more how they should best be implemented in different settings around the world. Documenting good practices allows for knowledge exchange to prevent transmission and improve health outcomes for people with HCV. This review found 13 well documented HCV good practices that have become the standard of care or that should become the standard of care as soon as possible. In 2013, highly effective direct-acting antiviral therapy became available, which has cure rates of over 95%. Together with this new therapy, evidence-based good practices can help countries eliminate viral hepatitis C.

摘要

必须采取重大措施,降低全球丙型肝炎病毒 (HCV) 的发病率和流行率,降低 HCV 感染导致的死亡率,从而实现世卫组织到 2030 年消除病毒性肝炎这一公共卫生威胁的目标。对整个护理连续体进行适当的流行病学监测,对于监测进展和发现需要解决的差距至关重要。消除 HCV 的工具在很大程度上已经建立,当前的问题更多的是如何在世界各地的不同环境中最好地实施这些工具。记录良好的实践经验有助于开展知识交流,防止 HCV 的传播,改善 HCV 感染者的健康结果。本综述发现了 13 项有充分记录的 HCV 良好实践经验,这些经验已经成为护理标准,或者应该尽快成为护理标准。2013 年,出现了高效的直接作用抗病毒治疗,其治愈率超过 95%。结合这种新疗法,循证良好的实践经验有助于各国消除丙型肝炎病毒。

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