Department of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, 127th Changle West Road, Xi'an 710032, Shaanxi, China.
Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, 79th Qingchun Road, Hangzhou 310003, Zhejiang, China.
Biomed Pharmacother. 2021 Jun;138:111482. doi: 10.1016/j.biopha.2021.111482. Epub 2021 Mar 16.
Intestinal ischemic reperfusion injury (IIRI) is a life-threatening condition with high morbidity and mortality in the clinic. IIRI was induced by intestinal ischemic diseases such as, small bowel transplantation, aortic aneurysm surgery, and strangulated hernias. Although related mechanisms have not been fully elucidated, during the last decade, researches have demonstrated that many factors are crucial in the pathological process, including oxidative stress (OS), epithelial barrier function disorder, and so on. Rats model, as the most applied animal IIRI model, provides specific targets for researches and therapeutic strategies. Moreover, various treatment strategies such as, anti-oxidative stress, anti-apoptosis, and anti-inflammation, have shown promising effects in alleviating IIRI. However, current researches cannot solve the clinical problems of IIRI, and specific treatment strategies are still needed to be exploited. This review focuses on a recommended experimental IIRI rat model and understanding of the involved mechanisms such as, OS, gut bacteria translocation, apoptosis, and necroptosis, aim at providing novel ideas for therapeutic strategies of IIRI.
肠缺血再灌注损伤（IIRI）是一种临床中具有高发病率和死亡率的危及生命的病症。IIRI 是由肠道缺血性疾病引起的，如小肠移植、腹主动脉瘤手术和绞窄性疝。尽管相关机制尚未完全阐明，但在过去十年中，研究表明许多因素在病理过程中至关重要，包括氧化应激（OS）、上皮屏障功能障碍等。大鼠模型作为最常用的动物 IIRI 模型，为研究和治疗策略提供了特定的靶点。此外，各种治疗策略，如抗氧化应激、抗细胞凋亡和抗炎，已显示出在缓解 IIRI 方面的有希望的效果。然而，目前的研究不能解决 IIRI 的临床问题，仍需要开发特定的治疗策略。本综述重点介绍了一种推荐的实验性 IIRI 大鼠模型，并深入了解涉及的机制，如 OS、肠道细菌易位、细胞凋亡和坏死性凋亡，旨在为 IIRI 的治疗策略提供新的思路。
