Son Y H, Kapp D S
Cancer. 1985 Jan 15;55(2):441-4. doi: 10.1002/1097-0142(19850115)55:2<441::aid-cncr2820550225>3.0.co;2-5.
Oral cavity and oropharyngeal cancer in younger adults is a rare entity with an incidence of 2.7% among 1014 patients seen or treated at the Department of Therapeutic Radiology, Yale - New Haven Medical Center between 1958 and 1980. Although there are reports of contrastingly divergent therapeutic experiences, the authors contend that even early stage cancers frequently fail definitive therapy with a rampant course, causing a rapidly fatal outcome. The three-year actuarial survival was a mere 17% at Yale. The authors speculate that younger adult oral cavity and oropharyngeal cancers are possibly related to a genetic disorder or immunodeficiency, and recommend aggressive surgical and radiotherapeutic approaches combined with possible adjuvant immunotherapy.
年轻成年人的口腔和口咽癌是一种罕见疾病，在1958年至1980年间于耶鲁-纽黑文医学中心放射治疗科就诊或接受治疗的1014例患者中，其发病率为2.7%。尽管有报道称治疗经验差异很大，但作者认为，即使是早期癌症，也常常因病程迅猛而导致确定性治疗失败，从而造成迅速致命的后果。在耶鲁大学，三年精算生存率仅为17%。作者推测，年轻成年人的口腔和口咽癌可能与遗传紊乱或免疫缺陷有关，并建议采取积极的手术和放射治疗方法，同时可能辅助免疫治疗。
