Medicine for Older People, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Aging Clin Exp Res. 2021 Apr;33(4):759-773. doi: 10.1007/s40520-021-01817-y. Epub 2021 Mar 20.
Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview of the commonly used pharmacological treatments for osteoporosis in older people.
骨质疏松症是一种常见的慢性代谢性骨病，与相当高的发病率和死亡率相关。随着骨质疏松症的患病率随年龄增长而增加，脆性骨折的发生率也将相应升高。本综述探讨了骨骼的起源，并考虑了与管理和治疗相关的骨骼内稳态的生理机制。随后讨论了骨质疏松症的继发性原因和肌骨减少症，以及老年人中常用的骨质疏松症药物治疗概述。
