Altern Ther Health Med. 2021 Jun;27(S1):162-177.
Dietary polyphenols, primarily categorized into flavonoids (flavanols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones) and nonflavonoids (stilbenes and phenolic acids) are reported to have health-promoting effects, such as antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, and cardioprotective properties. However, their applications in functional food and medications are limited due to their low bioavailability and insufficient systemic delivery. Nano-delivery system conveyances frameworks astoundingly influence the take-up properties of the stacked atoms because the molecule small shape, size, and surface properties of the nanoparticles apply a vital role in the improvement of the systemic delivery of polyphenols This includes nano-emulsion, nano-encapsulation, polymer nanoparticles (NPs), nano-liposomes, solid liquid nanoparticles, cyclodextrins, and polyphenol-loaded hydrogels. Nano-technology is a rapidly developing area that guarantees the improvement of materials with novel measurements, new properties, and more extensive scope for utilization. This review reports the different therapeutic applications of dietary polyphenols, their biological activities, and different nano-delivery systems successfully developed for overcoming the delivery challenges. These applications also seek to improve their bioavailability, reduce toxicity, and enhance dietary polyphenol uptake across the gastrointestinal tract.
膳食多酚主要分为黄酮类（黄烷醇、黄酮、黄烷-3-醇、花青素、黄烷酮和异黄酮）和非黄酮类（芪类和酚酸），具有促进健康的作用，如抗氧化、抗炎、抗肿瘤、抗菌、抗病毒和心脏保护作用。然而，由于其生物利用度低和全身递送不足，它们在功能性食品和药物中的应用受到限制。纳米递药系统的输送框架令人惊讶地影响了堆积原子的摄取特性，因为纳米粒子的分子小形状、大小和表面特性在多酚的全身递送改善中起着重要作用。这包括纳米乳液、纳米包封、聚合物纳米粒子 (NPs)、纳米脂质体、固体液体纳米粒子、环糊精和多酚负载水凝胶。纳米技术是一个快速发展的领域，它保证了具有新型测量、新性能和更广泛应用范围的材料的改进。本综述报告了膳食多酚的不同治疗应用、它们的生物活性以及为克服递送挑战而成功开发的不同纳米递药系统。这些应用还旨在提高它们的生物利用度、降低毒性并增强膳食多酚在胃肠道中的摄取。
