School of Rehabilitation Science, McMaster University, 1400 Main St. W. Room 435, IAHS, Hamilton, ON, L8S 1C7, Canada.
Respiratory Research, West Park Healthcare Centre, Toronto, ON, M6M 2J5, Canada.
Health Qual Life Outcomes. 2021 Mar 20;19(1):101. doi: 10.1186/s12955-021-01744-6.
Generic preference-based measures (GPBMs) are health-related quality of life (HRQoL) measures commonly used to evaluate the cost-utility of interventions in healthcare. However, the degree to which the content of GPBMs reflect the HRQoL of individuals with chronic obstructive pulmonary disease (COPD) has not yet been assessed. The purpose of this study was to examine the content and convergent validity of GPBMs in people with COPD.
COPD patients were recruited from healthcare centers in Ontario, Canada. The Patient-Generated Index (PGI) (an individualized HRQoL measure) and the RAND-36 (to obtain SF-6D scores; a GPBM) were administered. Life areas nominated with the PGI were coded using the International Classification of Functioning Disability and Health and mapped onto GPBMs.
We included 60 participants with a mean age of 70 and FEV1% predicted of 43. The mean PGI score was 34.55/100 and the top three overarching areas that emerged were: 'mobility' (25.93%), 'recreation and leisure' (25.19%) and 'domestic life' (19.26%). Mapping of the nominated areas revealed that the Quality of Well-Being scale covered the highest number of areas (84.62%), Health Utilities Indices covered the least (15.38% and 30.77%) and other GPBMs covered between 46 and 62%. A correlation of 0.32 was calculated between the SF-6D and the PGI.
The majority of GPBMs covered approximately half of the areas reported as being important to individuals with COPD. When areas relevant to COPD are not captured, HRQoL scores generated by these measures may inaccurately reflect patients' values and affect cost-effectiveness decisions.
通用偏好量表（GPBMs）是常用于评估医疗保健干预措施成本效益的健康相关生活质量（HRQoL）量表。然而，GPBMs 的内容在多大程度上反映了慢性阻塞性肺疾病（COPD）患者的 HRQoL 尚未得到评估。本研究旨在检查 COPD 患者的 GPBMs 的内容和收敛效度。
在加拿大安大略省的医疗中心招募 COPD 患者。患者生成指标（PGI）（一种个体化 HRQoL 量表）和 RAND-36（获得 GPBMs 的 SF-6D 评分）。使用国际功能、残疾和健康分类对 PGI 中提名的生活领域进行编码，并映射到 GPBMs 上。
我们纳入了 60 名平均年龄为 70 岁、FEV1%预计值为 43%的参与者。PGI 的平均得分为 34.55/100，前三个突出的领域是：“行动”（25.93%）、“娱乐和休闲”（25.19%）和“家庭生活”（19.26%）。提名领域的映射显示，健康幸福感量表涵盖了最多的领域（84.62%），健康效用指数涵盖的最少（15.38%和 30.77%），其他 GPBMs 涵盖了 46%至 62%之间的领域。SF-6D 与 PGI 之间计算出 0.32 的相关性。
大多数 GPBMs 涵盖了大约一半的 COPD 患者认为重要的领域。当与 COPD 相关的领域未被捕捉到时，这些措施生成的 HRQoL 评分可能不准确地反映患者的价值观，并影响成本效益决策。
