Pagan Jason, McDonough Chris, Vo Triet, Tonyushkin Alexey
Physics Department, University of Massachusetts Boston, Boston, MA 02125 USA.
Engineering Department, University of Massachusetts Boston, Boston, MA 02125 USA.
IEEE Trans Magn. 2021 Feb;57(2). doi: 10.1109/tmag.2020.3008596. Epub 2020 Jul 10.
Magnetic Particle Imaging (MPI) has shown great promise to surpass existing in vivo imaging modalities in some clinical applications. However, one of the challenges to MPI being translated into clinical practice has been the ability to scale up the selection field coils to surround a human body while being able to generate and drive a sufficiently strong magnetic field gradient. These requirements impose safety concerns as well as prohibitively high-power consumption in devices with large cylindrical volume. Therefore, we consider an alternative approach such as a single-sided topology, in which all the hardware is located on one side of the imaging volume accommodating larger subjects. Moreover, different from the previously implemented field-free point single-sided scanners, we realized a field-free line geometry providing, in principle, factor of ten higher signal and benefiting from a more robust back-projection image reconstruction technique. In this work, we present and characterize a first prototype of a single-sided MPI device with field-free-line geometry suited for in-vivo imaging of small animals as well as regions of interest in humans.
磁粒子成像（MPI）已显示出在某些临床应用中超越现有体内成像方式的巨大潜力。然而，将MPI转化为临床实践面临的挑战之一是能否扩大选择场线圈以包围人体，同时又能产生并驱动足够强的磁场梯度。这些要求既带来了安全问题，又导致具有大圆柱体积的设备功耗高得令人望而却步。因此，我们考虑一种替代方法，如单侧拓扑结构，其中所有硬件都位于成像区域的一侧，以容纳更大的受试者。此外，与先前实现的无场点单侧扫描仪不同，我们实现了一种无场线几何结构，原则上可提供高十倍的信号，并受益于更强大的反投影图像重建技术。在这项工作中，我们展示并表征了一种具有无场线几何结构的单侧MPI设备的首个原型，该设备适用于小动物体内成像以及人体感兴趣区域的成像。
