IEEE Trans Med Imaging. 2016 Apr;35(4):1056-65. doi: 10.1109/TMI.2015.2507187. Epub 2015 Dec 17.
Magnetic Particle Imaging is a new medical imaging modality, which detects superparamagnetic iron oxide nanoparticles. The particles are excited by magnetic fields. Most scanners have a tube-like measurement field and therefore, both the field of view and the object size are limited. A single-sided scanner has the advantage that the object is not limited in size, only the penetration depth is limited. A single-sided scanner prototype for 1D imaging has been presented in 2009. Simulations have been published for a 2D single-sided scanner and first 1D measurements have been carried out. In this paper, the first 2D single-sided scanner prototype is presented and the first calibration-based reconstruction results of measured 2D phantoms are shown. The field free point is moved on a Lissajous trajectory inside a 30 × 30 mm2 area. Images of phantoms with a maximal distance of 10 mm perpendicular to the scanner surface have been reconstructed. Different cylindrically shaped holes of phantoms have been filled with 6.28 μl undiluted Resovist. After the measurement and image reconstruction of the phantoms, particle volumes could be distinguished with a distance of 2 mm and 6 mm in vertical and horizontal direction, respectively.
磁共振成像是一种新的医学成像方式，用于检测超顺磁氧化铁纳米粒子。这些粒子通过磁场被激发。大多数扫描仪具有管状的测量场，因此，视野和物体尺寸都受到限制。单面扫描仪的优点是物体的尺寸不受限制，仅受穿透深度的限制。2009 年已经提出了用于 1D 成像的单面扫描仪原型。已经发表了用于 2D 单面扫描仪的模拟结果，并进行了首次 1D 测量。在本文中，提出了第一个 2D 单面扫描仪原型，并展示了首次基于校准的测量 2D 体模的重建结果。在 30×30mm2 的区域内，无磁场点在莱维曲线上移动。已经重建了与扫描仪表面垂直距离最大为 10mm 的体模图像。在对体模进行测量和图像重建后，可以区分填充有 6.28μl 未稀释 Resovist 的不同圆柱形体模孔。重建后，在垂直和水平方向上可以区分出距离为 2mm 和 6mm 的粒子体积。
