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通过严重急性呼吸感染(SARI)病例估计巴西各州新冠病毒病(COVID-19)的漏报情况

Estimation of COVID-19 Under-Reporting in the Brazilian States Through SARI.

作者信息

Paixão Balthazar, Baroni Lais, Pedroso Marcel, Salles Rebecca, Escobar Luciana, de Sousa Carlos, de Freitas Saldanha Raphael, Soares Jorge, Coutinho Rafaelli, Porto Fabio, Ogasawara Eduardo

机构信息

Federal Center for Technological Education of Rio de Janeiro, CEFET/RJ, Rio de Janeiro, Brazil.

Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil.

出版信息

New Gener Comput. 2021;39(3-4):623-645. doi: 10.1007/s00354-021-00125-3. Epub 2021 Mar 14.

Abstract

Due to its impact, COVID-19 has been stressing the academy to search for curing, mitigating, or controlling it. It is believed that under-reporting is a relevant factor in determining the actual mortality rate and, if not considered, can cause significant misinformation. Therefore, this work aims to estimate the under-reporting of cases and deaths of COVID-19 in Brazilian states using data from the InfoGripe. InfoGripe targets notifications of Severe Acute Respiratory Infection (SARI). The methodology is based on the combination of data analytics (event detection methods) and time series modeling (inertia and novelty concepts) over hospitalized SARI cases. The estimate of real cases of the disease, called novelty, is calculated by comparing the difference in SARI cases in 2020 (after COVID-19) with the total expected cases in recent years (2016-2019). The expected cases are derived from a seasonal exponential moving average. The results show that under-reporting rates vary significantly between states and that there are no general patterns for states in the same region in Brazil. The states of Minas Gerais and Mato Grosso have the highest rates of under-reporting of cases. The rate of under-reporting of deaths is high in the Rio Grande do Sul and the Minas Gerais. This work can be highlighted for the combination of data analytics and time series modeling. Our calculation of under-reporting rates based on SARI is conservative and better characterized by deaths than for cases.

摘要

由于其影响,新冠疫情一直在促使学术界寻找治愈、缓解或控制它的方法。据信,漏报是确定实际死亡率的一个相关因素,如果不加以考虑,可能会导致重大的错误信息。因此,这项工作旨在利用InfoGripe的数据估计巴西各州新冠病例和死亡的漏报情况。InfoGripe的目标是严重急性呼吸道感染(SARI)的通报。该方法基于对住院SARI病例的数据分析(事件检测方法)和时间序列建模(惯性和新颖性概念)的结合。通过比较2020年(新冠疫情之后)SARI病例的差异与近年来(2016 - 2019年)的总预期病例数,计算出该疾病实际病例数的估计值,即新颖性。预期病例数来自季节性指数移动平均线。结果表明,漏报率在各州之间差异显著,而且巴西同一地区的各州没有普遍模式。米纳斯吉拉斯州和马托格罗索州的病例漏报率最高。南里奥格兰德州和米纳斯吉拉斯州的死亡漏报率很高。这项工作因数据分析和时间序列建模的结合而受到关注。我们基于SARI计算的漏报率较为保守,而且用死亡情况来描述比用病例情况更好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ec6/7955907/67bbf2b2c155/354_2021_125_Fig1_HTML.jpg

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