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哥伦比亚卡萨纳雷地区女性的血清阳性率及相关因素

seroprevalence and associated factors in women in Casanare-Colombia.

作者信息

Díaz Angela Liliana Monroy, Pregonero Sigua Fabiana, Otálora Aura Shirley, Pedraza Bernal Adriana Maria

机构信息

Universidad de Boyacá, Carrera 2ª Este No. 64 - 169, Tunja, Boyacá, Colombia.

Empresa Social del Estado, Centro de Salud Pore, Casanare, Colombia.

出版信息

J Parasit Dis. 2021 Mar;45(1):89-95. doi: 10.1007/s12639-020-01280-y. Epub 2020 Oct 1.

Abstract

Chagas disease is caused by the parasite and transmitted mainly by triatomines and from mothers to children. In Colombia, this disease is a public health problem and due to its high endemicity and vertical transmission, women are susceptible populations that must be evaluated. Our objective was to determinate the seroprevalence and factors associated with women in Pore (Municipality), Casanare, Colombia. Cross-sectional study. A sample of 230 healthy volunteer women, 15 years or older, without previous diagnosis of Chagas disease was taken; the serological analysis was done using the Chagas ELISA IgG and IgM and indirect Hemagglutination (HAI) technique. In addition, a survey was applied to each participant in order to explore the presence of factors that could be associated with a positive test result. The seropostitivity found in Pore Casanare's women was 16.9% (39/230, 95% CI 12.1-21.7), additionally it was found that rural origin, the coexistence with animals, especially chickens, age, low level schooling and housing material are factors associated with infection in this population. The results of this study indicate the importance of conducting extensive seroepidemiological studies in populations of endemic areas, due to the difficulty in detecting cases in the acute phase; therefore, screening allows the establishment of a follow-up and treatment time line that contributes to the interruption of the transmission vertical.

摘要

恰加斯病由寄生虫引起,主要通过锥蝽传播以及母婴传播。在哥伦比亚,这种疾病是一个公共卫生问题,由于其高地方性流行率和垂直传播,女性是必须接受评估的易感人群。我们的目标是确定哥伦比亚卡萨纳雷省波雷市女性的血清阳性率及相关因素。横断面研究。选取了230名15岁及以上、未曾被诊断出患有恰加斯病的健康女性志愿者作为样本;血清学分析采用恰加斯酶联免疫吸附测定法检测IgG和IgM以及间接血凝技术。此外,还对每位参与者进行了一项调查,以探究可能与检测结果呈阳性相关的因素。在波雷市卡萨纳雷的女性中发现血清阳性率为16.9%(39/230,95%置信区间12.1 - 21.7),此外还发现农村出身、与动物尤其是鸡共同生活、年龄、低教育水平和住房材料是该人群感染的相关因素。这项研究的结果表明,由于急性期病例难以检测,在流行地区人群中开展广泛的血清流行病学研究具有重要意义;因此,筛查有助于建立后续跟踪和治疗时间线,从而有助于阻断垂直传播。

相似文献

本文引用的文献

1
American Trypanosomiasis (Chagas Disease).美国锥虫病(恰加斯病)。
Infect Dis Clin North Am. 2019 Mar;33(1):119-134. doi: 10.1016/j.idc.2018.10.015.
2
Congenital Chagas disease: an update.先天性恰加斯病:最新进展
Mem Inst Oswaldo Cruz. 2015 May;110(3):363-8. doi: 10.1590/0074-02760140405. Epub 2015 Mar 6.
7
An unfolding tragedy of Chagas disease in North America.北美恰加斯病一场正在上演的悲剧。
PLoS Negl Trop Dis. 2013 Oct 31;7(10):e2300. doi: 10.1371/journal.pntd.0002300. eCollection 2013.
10
Global economic burden of Chagas disease: a computational simulation model.全球恰加斯病的经济负担:一个计算模拟模型。
Lancet Infect Dis. 2013 Apr;13(4):342-8. doi: 10.1016/S1473-3099(13)70002-1. Epub 2013 Feb 8.

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