Zhang Ya-Nan, Wang Mei-Hua, Yu Wen-Cheng, Cheng Wei, Cong Jin-Peng, Huang Xue-Peng, Wang Fang-Fang
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China.
Department of Respiratory and Critical Care Medicine, People's Hospital of Rizhao Lanshan, Rizhao 276800, Shandong Province, China.
World J Clin Cases. 2022 May 26;10(15):4949-4956. doi: 10.12998/wjcc.v10.i15.4949.
In most cases of yellow nail syndrome (YNS), the classic triad of yellow nails, lymphedema and respiratory manifestations rarely manifest simultaneously. Therefore, diagnosis is delayed or frequently missed.
We report a 62-year-old YNS patient presenting with bilateral pleural, pericardial and peritoneal effusions who, 2 mo later, developed minimal-change nephrotic syndrome. After treatment with vitamin E, clarithromycin and prednisone for 3 mo, effusions in the chest, pericardium and abdominal cavity decreased while urine protein levels returned to within normal ranges.
Clinicians should consider the possibility of YNS for patients presenting with multiple serous effusions and nephrotic syndromes.
在大多数黄甲综合征(YNS)病例中,黄甲、淋巴水肿和呼吸系统表现这一经典三联征很少同时出现。因此,诊断往往延迟或经常被漏诊。
我们报告了一名62岁的YNS患者,该患者出现双侧胸腔、心包和腹腔积液,2个月后发展为微小病变型肾病综合征。经维生素E、克拉霉素和泼尼松治疗3个月后,胸腔、心包和腹腔积液减少,尿蛋白水平恢复至正常范围。
对于出现多发性浆膜腔积液和肾病综合征的患者,临床医生应考虑黄甲综合征的可能性。