Xie Jinlan, Fang Ping, Zhang Zhihao, Luo Ronglei, Dai Bibing
Department of Psychology, Capital Normal University, Beijing, China.
Department of Psychiatry and Psychology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Front Psychiatry. 2021 Mar 4;12:644882. doi: 10.3389/fpsyt.2021.644882. eCollection 2021.
Previous studies have shown that the behavioral inhibition/activation systems (BIS/BAS) have substantial effects on substance use disorder and emotional disorders, and substance use disorder and emotional disorders often occur; in particular, females with substance use disorder are more likely to also have serious emotional disorders including depression than their male counterparts. However, the associations between the BIS/BAS and depression in females with substance use disorder have received little attention. Furthermore, the underlying mechanisms of these relations are largely unknown. The present study examines the mediating roles of intolerance of uncertainty and anhedonia in the associations between the BIS/BAS and depression among females with substance use disorder from the Research Domain Criteria (RDoC) framework. A total of 303 females with substance use disorder from a compulsory substance abuse detention center were tested using a cross-sectional survey involving BIS/BAS Scales, Intolerance of Uncertainty Scale, Snaith-Hamilton Pleasure Scale, and Center for Epidemiologic Studies Depression Scale. The path analysis model revealed that both the BIS and BAS had a direct effect on depression, that the BIS had an indirect effect on depression through intolerance of uncertainty, and that the BAS had an indirect effect on depression via anhedonia. These findings contribute to a more thorough understanding of how the BIS/BAS influence depression among females with substance use disorder and suggest that the utility of targeting these associations in treatments would help reduce depression in females with substance use disorder.
先前的研究表明，行为抑制/激活系统（BIS/BAS）对物质使用障碍和情绪障碍有重大影响，且物质使用障碍和情绪障碍经常同时出现；特别是，患有物质使用障碍的女性比男性更有可能同时患有包括抑郁症在内的严重情绪障碍。然而，BIS/BAS与患有物质使用障碍的女性的抑郁症之间的关联却很少受到关注。此外，这些关系的潜在机制在很大程度上尚不清楚。本研究从研究领域标准（RDoC）框架出发，考察了不确定性不耐受和快感缺失在BIS/BAS与患有物质使用障碍的女性的抑郁症之间的关联中的中介作用。对一个强制戒毒所的303名患有物质使用障碍的女性进行了横断面调查，使用了BIS/BAS量表、不确定性不耐受量表、斯奈斯-汉密尔顿快感量表和流行病学研究中心抑郁量表。路径分析模型显示，BIS和BAS对抑郁症都有直接影响，BIS通过不确定性不耐受对抑郁症有间接影响，BAS通过快感缺失对抑郁症有间接影响。这些发现有助于更全面地理解BIS/BAS如何影响患有物质使用障碍的女性的抑郁症，并表明在治疗中针对这些关联将有助于减少患有物质使用障碍的女性的抑郁症。
