Moodi Zahra, Bagherzade Ghodsieh, Peters Janny
Department of Chemistry, University of Birjand, Birjand 97175-615, Iran.
Department of Plant Systems Physiology, Radboud University Nijmegen, Nijmegen 6525, AJ, Netherlands.
Bioinorg Chem Appl. 2021 Mar 3;2021:8818452. doi: 10.1155/2021/8818452. eCollection 2021.
Quercetin (3,3',4',5,7-pentahydroxyflavone) is one of the dietary flavonoids, distributed in medicinal plants, vegetables, and fruits. Quercetin has the ability to bind with several metal ions to increase its biological activities. In the last two decades, quercetin has attracted considerable attention due to the biological and pharmaceutical activities such as antioxidant, antibacterial, and anticancer. In the present study, quercetin and ethanolamine were used for the synthesis Schiff base complex, which was characterized by IR, H NMR, and C NMR spectroscopy. The Schiff base has been employed as a ligand for the synthesis of novel nanoscale Cu (II) complex. The product was characterized by FT-IR spectroscopy, FESEM, and XRD. Significantly, the product showed remarkable catalytic activity towards the oxidation of primary and secondary alcohols. The antibacterial activity of the final product was assessed against (Gram-positive) and (Gram-negative) bacteria using an inhibition zone test. The synthesized nanoscale Cu (II) complex exhibited a strong antibacterial activity against both Gram-positive and Gram-negative bacteria.
槲皮素（3,3',4',5,7-五羟基黄酮）是一种膳食类黄酮，分布于药用植物、蔬菜和水果中。槲皮素能够与多种金属离子结合以增强其生物活性。在过去二十年中，槲皮素因其抗氧化、抗菌和抗癌等生物及药理活性而备受关注。在本研究中，槲皮素与乙醇胺用于合成席夫碱配合物，通过红外光谱（IR）、氢核磁共振（¹H NMR）和碳核磁共振（¹³C NMR）对其进行表征。该席夫碱已被用作配体来合成新型纳米级铜（II）配合物。产物通过傅里叶变换红外光谱（FT-IR）、场发射扫描电子显微镜（FESEM）和X射线衍射（XRD）进行表征。值得注意的是，该产物对伯醇和仲醇的氧化表现出显著的催化活性。使用抑菌圈试验评估最终产物对金黄色葡萄球菌（革兰氏阳性）和大肠杆菌（革兰氏阴性）的抗菌活性。合成的纳米级铜（II）配合物对革兰氏阳性和革兰氏阴性细菌均表现出较强的抗菌活性。
