变应性鼻炎患者中的血脂异常：发生率及危险因素
Dyslipidemia among allergic rhinitis patients: Frequency and risk factors.
作者信息
Sheha Dina S, El-Korashi Lobna A, AbdAllah Amany M, El-Begermy Marwa M, Elmahdi Amira R
机构信息
Department of Internal Medicine, Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
出版信息
World Allergy Organ J. 2021 Mar 5;14(3):100523. doi: 10.1016/j.waojou.2021.100523. eCollection 2021 Mar.
BACKGROUND
Although cumulative data strongly suggest an association between dyslipidemia and allergic disorders, especially asthma, evidence regarding allergic rhinitis (AR) is lacking. We aimed to assess frequency and associated risk factors of dyslipidemia among patients with AR.
METHODS
The current study is a cross-sectional study that recruited 150 AR patients by systematic randomization. Blood samples for serum lipid profile, total immunoglobulin E (IgE) and serum interleukin-17A (IL-17A) were withdrawn from all patients.
RESULTS
Dyslipidemia was prevalent in 84 AR patients (56%). Higher levels of total IgE, IL17-A, and sensitization to hay dust and mixed mites significantly increased the risk of dyslipidemia among AR patients by 1.004, 1.062, 4.057 and 3.652 respectively ( < 0.05).
CONCLUSION
High serum total IgE level, high serum IL-17A level, and sensitization to hay dust and mixed mites are independent risk factors for dyslipidemia among AR patients.
背景
尽管累积数据强烈提示血脂异常与过敏性疾病，尤其是哮喘之间存在关联，但关于变应性鼻炎（AR）的相关证据仍很缺乏。我们旨在评估AR患者中血脂异常的发生率及其相关危险因素。
方法
本研究为一项横断面研究，通过系统随机抽样招募了150例AR患者。采集所有患者的血液样本，检测血清脂质谱、总免疫球蛋白E（IgE）和血清白细胞介素-17A（IL-17A）。
结果
84例AR患者（56%）存在血脂异常。总IgE、IL-17A水平升高以及对干草尘和混合螨过敏，分别使AR患者血脂异常风险显著增加1.004、1.062、4.057和3.652倍（P<0.05）。
结论
血清总IgE水平升高、血清IL-17A水平升高以及对干草尘和混合螨过敏是AR患者血脂异常的独立危险因素。
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