Yang Zhenguo, He Tianle, Chen Qingyun
Laboratory for Bio-Feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing, China.
Front Cell Dev Biol. 2021 Mar 5;9:619329. doi: 10.3389/fcell.2021.619329. eCollection 2021.
The muscle growth and development of livestock animals is a complex, multistage process, which is regulated by many factors, especially the genes related to muscle development. In recent years, it has been reported frequently that circular RNAs (circRNAs) are involved widely in cell proliferation, cell differentiation, and body development (including muscle development). However, the research on circRNAs in muscle growth and development of livestock animals is still in its infancy. In this paper, we briefly introduce the discovery, classification, biogenesis, biological function, and degradation of circRNAs and focus on the molecular mechanism and mode of action of circRNAs as competitive endogenous RNAs in the muscle development of livestock and poultry. In addition, we also discuss the regulatory mechanism of circRNAs on muscle development in livestock in terms of transcription, translation, and mRNAs. The purpose of this article is to discuss the multiple regulatory roles of circRNAs in the process of muscle development in livestock, to provide new ideas for the development of a new co-expression regulation network, and to lay a foundation for enriching livestock breeding and improving livestock economic traits.
家畜的肌肉生长和发育是一个复杂的多阶段过程，受多种因素调控，尤其是与肌肉发育相关的基因。近年来，经常有报道称环状RNA（circRNA）广泛参与细胞增殖、细胞分化和机体发育（包括肌肉发育）。然而，关于circRNA在家畜肌肉生长和发育方面的研究仍处于起步阶段。本文简要介绍了circRNA的发现、分类、生物合成、生物学功能及降解，并重点阐述了circRNA作为竞争性内源RNA在家禽家畜肌肉发育中的分子机制及作用方式。此外，我们还从转录、翻译和mRNA方面探讨了circRNA对家畜肌肉发育的调控机制。本文旨在探讨circRNA在家畜肌肉发育过程中的多重调控作用，为构建新的共表达调控网络提供新思路，并为丰富家畜育种和改善家畜经济性状奠定基础。
