Liossis Stamatis Nick, Staveri Chrysanthi
Division of Rheumatology, Department of Internal Medicine, Patras University Hospital, Patras, Greece.
Division of Rheumatology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece.
Front Med (Lausanne). 2021 Mar 5;8:655100. doi: 10.3389/fmed.2021.655100. eCollection 2021.
Systemic lupus erythematosus (SLE) is a chronic autoimmune multisystem disease with a variable presentation and manifestations ranging from mild to severe or even life-threatening. There is an ongoing and unmet need for novel, disease-specific, effective and safe treatment modalities. The aim of this review is to summarize data on SLE treatment that have emerged over the last 3 years. We will put emphasis on studies evaluating potential treatments on severe lupus manifestations such as lupus nephritis. Despite the existence of several therapeutic agents in SLE, the disease keeps causing significant morbidity. It is encouraging that a variety of therapeutic options are currently under investigation, although there are occasional trial failures.
系统性红斑狼疮（SLE）是一种慢性自身免疫性多系统疾病，其表现多样，症状从轻到重，甚至危及生命。对于新型、针对疾病的、有效且安全的治疗方式，一直存在着未被满足的需求。本综述的目的是总结过去3年中出现的有关SLE治疗的数据。我们将重点关注评估针对严重狼疮表现（如狼疮性肾炎）的潜在治疗方法的研究。尽管SLE有多种治疗药物，但该疾病仍会导致严重的发病率。令人鼓舞的是，目前有多种治疗选择正在研究中，尽管偶尔会有试验失败的情况。
