Vonnahme Kimberly A, Mueller Adam, Nelson Daniel A, Vasquez-Hidalgo Manuel Alexander, Amodie Deborah, Short Thomas H, Mellencamp Martha A, Galina Pantoja Lucina
Outcomes Research, Zoetis, Inc., 10 Sylvan Way, Parsippany, NJ 07054, USA.
Swine Services Unlimited, Inc. 6212 155th St NE, Rice, MN 56367, USA.
Transl Anim Sci. 2021 Feb 8;5(1):txab023. doi: 10.1093/tas/txab023. eCollection 2021 Jan.
Mass medication to manage population health can be achieved by providing therapeutics in the drinking water. Young nursery pigs are highly sensitive to the flavor and smell of water. Medications that reduce water palatability often lead to an interruption in water and feed intake. With the availability of several generic water-soluble antimicrobials for pigs, questions have arisen about their palatability compared with the original product. In this study, we compared the intake of water containing tiamulin hydrogen fumarate from two different manufacturers with the intake of unmedicated water. The hypothesis was that the intake of tiamulin-containing water would be similar to unmedicated water. Water intake was monitored upon entry into the nursery and just prior to leaving the nursery. Also, average daily gain (ADG) and feed efficiency (FE) were determined. A total of 300 pigs were individually weighed (4.2-10.9 kg; avg = 6.8 kg) for randomization to pen ( = 30 pens). The experiment had two time points: 1) early nursery (periods 1-3) and 2) late nursery (period 4). Pens were randomly assigned to a sequence (period 1-3) in a crossover experimental design containing three 10-d periods, with 5 d for the resetting of baseline where unmedicated water was provided followed by 5 d on tiamulin source addition [i.e., Triamulox (Zoetis, Parsippany, NJ); Denagard (Elanco Animal Health, Greenfield, IN)] or unmedicated water. After period 3 was concluded, all pens were given unmedicated water (via nipple waterers) and the number of pigs per pen was reduced to six pigs to maintain adequate space per pig. Ten days prior to pigs leaving the nursery, a fourth period was performed. After a 5-d water baseline was achieved, pens were treated with either unmedicated water or Triamulox- or Denagard-containing water. Pigs had ad libitum access to water and feed. During the testing periods, daily water intake was measured by a cup water system in each pen. Feed intake was measured every 5 d. There was no effect of treatment on initial body weights or weights at the beginning or end of each period ( ≥ 0.51). Therefore, there was no effect of treatment on ADG ( ≥ 0.23). Water intake ( ≥ 0.16) and FE ( ≥ 0.35) were not affected by treatment. Water consumption was similar among all treatments in each of the four periods. There appears to be no aversion to water intake when tiamulin hydrogen fumarate is added to the drinking water.
通过在饮用水中添加治疗药物可以实现群体健康的大规模给药。幼龄保育猪对水的味道和气味高度敏感。降低水适口性的药物常常导致水和饲料摄入量的中断。随着几种猪用通用水溶性抗菌药物的出现，与原产品相比，其适口性问题也随之产生。在本研究中，我们比较了来自两个不同制造商的含延胡索酸泰妙菌素的水的摄入量与未添加药物的水的摄入量。假设是含泰妙菌素的水的摄入量与未添加药物的水相似。在进入保育舍时和即将离开保育舍时监测水摄入量。此外，还测定了平均日增重（ADG）和饲料效率（FE）。总共300头猪个体称重（4.2 - 10.9千克；平均 = 6.8千克），以便随机分配到栏舍（ = 30个栏舍）。实验有两个时间点：1）保育早期（第1 - 3阶段）和2）保育后期（第4阶段）。在交叉实验设计中，栏舍被随机分配到一个序列（第1 - 3阶段），该设计包含三个10天的阶段，其中5天提供未添加药物的水以重置基线，随后5天添加泰妙菌素来源的药物[即，泰妙菌素（硕腾公司，新泽西州 Parsippany）；德纳加德（礼蓝动物保健公司，印第安纳州 Greenfield）]或未添加药物的水。在第3阶段结束后，所有栏舍都提供未添加药物的水（通过乳头饮水器），并且每个栏舍的猪数量减少到6头，以确保每头猪有足够的空间。在猪离开保育舍前10天，进行第四个阶段。在达到5天的水基线后，栏舍用未添加药物的水或含泰妙菌素或德纳加德的水进行处理。猪可以自由饮水和采食。在测试期间，每个栏舍通过杯式水系统测量每日水摄入量。每5天测量一次采食量。处理对初始体重或每个阶段开始或结束时的体重没有影响（≥0.51）。因此，处理对ADG没有影响（≥0.23）。水摄入量（≥0.16）和FE（≥0.35）不受处理影响。在四个阶段中的每个阶段，所有处理之间的水消耗量相似。当在饮用水中添加延胡索酸泰妙菌素时，似乎不存在对水摄入的厌恶。
