Blazes Marian, Lee Cecilia S
Department of Ophthalmology, University of Washington, Seattle, WA 98104, USA.
Karalis Johnson Retina Center, Seattle, WA 98109, USA.
Adv Geriatr Med Res. 2021;3(2). doi: 10.20900/agmr20210008. Epub 2021 Mar 1.
The eye and brain share common mechanisms of aging and disease, thus the retina is an essential source of accessible information about neurodegenerative processes occurring in the brain. Advances in retinal imaging have led to the discovery of many potential biomarkers of Alzheimer's disease, although further research is needed to validate these associations. Understanding the mechanisms of retinal disease in the context of aging will extend our knowledge of AD and may enable advancements in diagnosis, monitoring, and treatment.
眼睛和大脑有着共同的衰老及疾病机制，因此视网膜是获取有关大脑中神经退行性过程信息的重要来源。视网膜成像技术的进步已促成许多阿尔茨海默病潜在生物标志物的发现，不过仍需进一步研究来验证这些关联。在衰老背景下理解视网膜疾病的机制将拓展我们对阿尔茨海默病的认识，并可能推动诊断、监测及治疗方面的进展。
