Chen Qing, Qiu Yu, Chen Lin, Lin Jing, Yan Ling-Jun, Bao Xiao-Dan, Lin Li-Song, Pan Li-Zhen, Shi Bin, Zheng Xiao-Yan, Chen Fa, He Bao-Chang, Wang Jing, Liu Feng-Qiong
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China.
Community Dent Oral Epidemiol. 2022 Apr;50(2):83-90. doi: 10.1111/cdoe.12633. Epub 2021 Mar 21.
Evidence on serum arsenic and oral cancer risk was limited. We aimed to evaluate the association between serum arsenic and the risk of oral cancer in a southeast China population.
Serum arsenic was determined for 325 oral cancer patients and 648 controls using inductively coupled plasma-mass spectrometry (ICP-MS). Logistic regression and restricted cubic spline were analysed the association between serum arsenic level and oral cancer risk, and crude and adjusted odds ratios (aOR) with 95% confidence interval (95% CI) were calculated. Factors adjusted for included age, gender, BMI, smoking, drinking, education, residence, marital status and dietary factors. Stratification analysis was further performed according to drinking, smoking and dietary characteristics.
Serum arsenic level was lower in the case group (P = 19.2μg/L, IQR = 11.6 ~ 26.4μg/L) than in the control group (P = 30.2 μg/L, IQR = 25.0 ~ 36.4 μg/L). An inverse but nonlinear association was observed between arsenic level and oral cancer risk by restricted cubic spline. These with moderate serum arsenic levels had a lower risk of oral cancer than those with low levels (OR = 0.11; 95%CI: 0.07-0.18), after adjusting for demographic and dietary intake factors. We also kept serum arsenic as a continuous variable in a regression model, where a similar inverse association between arsenic and oral cancer was observed, with OR = 0.86 (95%CI: 0.84-0.88). Stratification analysis revealed no significant multiplicative interactions between serum arsenic and smoking, drinking or dietary intake.
Serum arsenic is inversely related to oral cancer risk. Relative to those with low levels of arsenic, people with moderate serum arsenic levels had a lower risk of oral cancer. If confirmed, serum arsenic level may be a useful predictive marker for oral cancer risk.
血清砷与口腔癌风险的证据有限。我们旨在评估中国东南部人群血清砷与口腔癌风险之间的关联。
采用电感耦合等离子体质谱法（ICP-MS）测定325例口腔癌患者和648例对照者的血清砷。采用逻辑回归和受限立方样条分析血清砷水平与口腔癌风险之间的关联，并计算粗比值比和调整后的比值比（aOR）及其95%置信区间（95%CI）。调整的因素包括年龄、性别、体重指数、吸烟、饮酒、教育程度、居住地、婚姻状况和饮食因素。根据饮酒、吸烟和饮食特征进一步进行分层分析。
病例组血清砷水平（中位数=19.2μg/L，四分位数间距=11.626.4μg/L）低于对照组（中位数=30.2μg/L，四分位数间距=25.036.4μg/L）。通过受限立方样条观察到砷水平与口腔癌风险呈负相关但非线性关系。在调整人口统计学和饮食摄入因素后，血清砷水平中等者患口腔癌的风险低于低水平者（OR=0.11；95%CI：0.07-0.18）。我们还将血清砷作为回归模型中的连续变量，观察到砷与口腔癌之间存在类似的负相关，OR=0.86（95%CI：0.84-0.88）。分层分析显示血清砷与吸烟、饮酒或饮食摄入之间无显著的相乘交互作用。
血清砷与口腔癌风险呈负相关。相对于砷水平低的人，血清砷水平中等的人患口腔癌的风险较低。如果得到证实，血清砷水平可能是口腔癌风险的一个有用预测指标。
