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松香烷型二萜类化合物:结构多样性与治疗潜力的深入了解。

Abietane-Type Diterpenoids: Insights into Structural Diversity and Therapeutic Potential.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.

Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Chem Biodivers. 2024 Oct;21(10):e202400808. doi: 10.1002/cbdv.202400808. Epub 2024 Sep 12.

Abstract

The abietane-type diterpenoids are among the most significant diterpene subsets found in hundreds of plant species belonging to various families. Among which, the members of the genus Salvia and Euphorbia are rich in abietane diterpenoids. Because of the chemical diversity and notable bioactivities, such as anticancer, antiinflammatory, antimicrobial, and antioxidant activities, they are attractive. Herein, recent advances in the isolation and characterization of abietanes from natural sources, as well as their biological activities, from 2015 up to 2024 are reviewed. During this time, over 300 abietanes with diverse structures have been discovered.

摘要

松香烷型二萜类化合物是在属于不同科的数百种植物物种中发现的最重要的二萜类化合物亚类之一。其中,鼠尾草属和大戟属的成员富含松香烷二萜类化合物。由于其化学多样性和显著的生物活性,如抗癌、抗炎、抗菌和抗氧化活性,它们具有吸引力。本文综述了 2015 年至 2024 年期间从天然来源中分离和鉴定松香烷以及它们的生物活性的最新进展。在此期间,发现了 300 多种具有不同结构的松香烷。

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