人类癌症中HNF1A的综合生物信息学分析
Integrated bioinformatic analysis of HNF1A in human cancers.
作者信息
Zhang Enfan, Huang Xi, He Jingsong
机构信息
Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Institute of Hematology, Zhejiang University, China.
出版信息
J Int Med Res. 2021 Mar;49(3):300060521997326. doi: 10.1177/0300060521997326.
OBJECTIVES
Cancer is a threat to human health, and many molecules are involved in the transformation of malignant cells. Hepatocyte nuclear factor 1A (HNF1A) is an important transcription factor that regulates multiple biological processes. Our research focused on elucidating the expression and function of HNF1A in cancer through bioinformatic analysis.
METHODS
UALCAN, Kaplan-Meier plotter, COSMIC, Tumor IMmune Estimation Resource, and Cancer Regulome were used to obtain relevant data for HNF1A.
RESULTS
HNF1A was abnormally expressed in multiple cancers, and its expression was associated with differences in overall survival in patients with cancer. HNF1A mutations widely exist in tumors and interact with different genes involved in various processes. Additionally, we found that HNF1A was associated with the infiltration of immune cells, and it affected the prognostic value of these cells in some cancers.
CONCLUSIONS
HNF1A plays a crucial role in cancer, and it may represent a biomarker and target for future cancer immunotherapy.
目的
癌症是对人类健康的一种威胁，许多分子参与恶性细胞的转化。肝细胞核因子1A（HNF1A）是一种调节多种生物学过程的重要转录因子。我们的研究聚焦于通过生物信息学分析阐明HNF1A在癌症中的表达及功能。
方法
使用UALCAN、Kaplan-Meier绘图仪、COSMIC、肿瘤免疫评估资源和癌症调控组来获取HNF1A的相关数据。
结果
HNF1A在多种癌症中异常表达，其表达与癌症患者的总生存期差异相关。HNF1A突变广泛存在于肿瘤中，并与参与各种过程的不同基因相互作用。此外，我们发现HNF1A与免疫细胞浸润相关，并且在某些癌症中它影响这些细胞的预后价值。
结论
HNF1A在癌症中起关键作用，它可能代表未来癌症免疫治疗的一种生物标志物和靶点。
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