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基于数据挖掘的人类癌症中Siglec-15 mRNA的综合分析

Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining.

作者信息

Li Qiu-Ting, Huang Zao-Zao, Chen Yao-Bin, Yao Hong-Yi, Ke Zun-Hui, He Xiao-Xiao, Qiu Meng-Jun, Wang Meng-Meng, Xiong Zhi-Fan, Yang Sheng-Li

机构信息

Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.

Yangchunhu community Hospital, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.

出版信息

J Cancer. 2020 Feb 10;11(9):2453-2464. doi: 10.7150/jca.38747. eCollection 2020.

DOI:10.7150/jca.38747
PMID:32201516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7066007/
Abstract

: Cancer is expected to be the leading cause of death worldwide within the 21st century and is the single most important obstacle to extending life expectancy. Unfortunately, the most effective approach to combating cancers remains a complex and unsolved problem. Siglec-15 is a member of the Siglec family and plays a conserved regulatory role in the immune system of vertebrates. Previous studies on Siglec-15 have focused on its function in osteoclast regulation. The purpose of this study was to explore the significance of Siglec-15 mRNA in human cancer mainly based on information obtained from online databases. : Data were collected from several online databases. Serial analysis of gene expression (SAGE) and Virtual Northern, UALCAN Database Analysis, Catalog of Somatic Mutations in Cancer (COSMIC) analysis, the cBio cancer genomics portal, Cancer Regulome tools and data, Kaplan-Meier Plotter Analysis and the UCSC Xena website were used to analyze the data. : Compared with normal tissues, Siglec-15 up-regulation was widely observed in tuomrs. Differences in Siglec-15 expression were associated with different prognoses. Siglec-15 mutations are widely observed in tumors and interact with different genes in different cancer types. : Siglec-15 is a potential target for the expansion of cancer immunotherapy.

摘要

预计癌症将在21世纪成为全球主要死因，并且是延长预期寿命的最重要单一障碍。不幸的是，对抗癌症最有效的方法仍然是一个复杂且未解决的问题。唾液酸结合免疫球蛋白样凝集素15（Siglec-15）是Siglec家族的成员，在脊椎动物免疫系统中发挥保守的调节作用。先前关于Siglec-15的研究主要集中在其在破骨细胞调节中的功能。本研究的目的是主要基于从在线数据库获得的信息，探讨Siglec-15 mRNA在人类癌症中的意义。

数据从多个在线数据库收集。使用基因表达系列分析（SAGE）和虚拟Northern分析、UALCAN数据库分析、癌症体细胞突变目录（COSMIC）分析、cBio癌症基因组学门户、癌症调控组工具和数据、Kaplan-Meier Plotter分析以及UCSC Xena网站来分析数据。

与正常组织相比，在肿瘤中广泛观察到Siglec-15上调。Siglec-15表达的差异与不同的预后相关。Siglec-15突变在肿瘤中广泛存在，并在不同癌症类型中与不同基因相互作用。

Siglec-15是癌症免疫治疗扩展的潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ea0/7066007/580f563c726e/jcav11p2453g006.jpg
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