Gwon Yonghyun, Park Sunho, Kim Woochan, Han Taeseong, Kim Hyoseong, Kim Jangho
Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju, 61186, Republic of Korea.
J Biol Eng. 2021 Mar 22;15(1):12. doi: 10.1186/s13036-021-00263-8.
The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however, it has critical limitations. Bone tissue engineering has been proposed as a viable alternative, not only for replacing the current standard treatment, but also for producing complete regeneration of bone tissue without complex surgical treatments or tissue transplantation. In this study, we proposed a transplantable radially patterned scaffold for bone regeneration that was defined by capillary force lithography technology using biodegradable polycaprolactone polymer.
The radially patterned transplantable biodegradable scaffolds had a radial structure aligned in a central direction. The radially aligned pattern significantly promoted the recruitment of host cells and migration of osteoblasts into the defect site. Furthermore, the transplantable scaffolds promoted regeneration of critical-sized bone defects by inducing cell migration and differentiation.
Our findings demonstrated that topographically defined radially patterned transplantable biodegradable scaffolds may have great potential for clinical application of bone tissue regeneration.
在现代矫形医学中，大面积临界尺寸骨缺损的愈合仍然是一项临床挑战。治疗临界尺寸骨缺损的当前金标准是自体骨移植；然而，它存在严重局限性。骨组织工程已被提出作为一种可行的替代方案，不仅用于替代当前的标准治疗，还用于在无需复杂手术治疗或组织移植的情况下实现骨组织的完全再生。在本研究中，我们提出了一种用于骨再生的可移植径向图案化支架，其由使用可生物降解聚己内酯聚合物的毛细力光刻技术定义。
径向图案化的可移植可生物降解支架具有沿中心方向排列的径向结构。径向排列的图案显著促进了宿主细胞的募集和成骨细胞向缺损部位的迁移。此外，可移植支架通过诱导细胞迁移和分化促进了临界尺寸骨缺损的再生。
我们的研究结果表明，地形学定义的径向图案化可移植可生物降解支架在骨组织再生的临床应用中可能具有巨大潜力。
