Kim Sujin, Gwon Yonghyun, Park Sunho, Kim Woochan, Jeon Yubin, Han Taeseong, Jeong Hoon Eui, Kim Jangho
Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Republic of Korea.
J Mech Behav Biomed Mater. 2021 Feb;114:104167. doi: 10.1016/j.jmbbm.2020.104167. Epub 2020 Oct 31.
Biomedical patches have been known as important biomaterial-based medical devices for the clinical treatment of tissue and organ diseases. Inspired by the extracellular matrix-like aligned nanotopographical pattern as well as the unique physical and biocompatible properties of gelatin, we developed strength-enhanced biomedical patches by coating gelatin onto the nanopatterned surface of polycaprolactone (PCL). The relative contributions of the nanotopographical pattern (physical factor) and gelatin coating (chemical factor) in enhancing the mechanical and adhesive properties of PCL were quantitatively investigated. The nanotopographical pattern increased the surface area of PCL, allowing more gelatin to be coated on its surface. The biomedical patch made from gelatin-coated nanopatterned PCL showed strong mechanical and adhesive properties (tensile strength: ~14.5 MPa; Young's modulus: ~60.2 MPa; and normal and shear adhesive forces: ~1.81 N/cm and ~352.3 kPa) as well as good biocompatibility. Although the nanotopographical pattern or gelatin coating alone could enhance these physical properties of PCL in both dry and wet environmental conditions, both factors in combination further strengthened the properties, indicating the importance of synergistic cues in driving the mechanical behavior of biomedical materials. This strength-enhanced biomedical patch will be especially useful for the treatment of tissues such as cartilage, tendon, and bone.
生物医学贴片作为基于生物材料的重要医疗设备，已被用于组织和器官疾病的临床治疗。受细胞外基质样排列的纳米拓扑图案以及明胶独特的物理和生物相容性特性的启发，我们通过将明胶涂覆在聚己内酯（PCL）的纳米图案表面上，开发出了强度增强的生物医学贴片。定量研究了纳米拓扑图案（物理因素）和明胶涂层（化学因素）对增强PCL力学和粘附性能的相对贡献。纳米拓扑图案增加了PCL的表面积，使更多的明胶能够涂覆在其表面。由涂有明胶的纳米图案化PCL制成的生物医学贴片具有很强的力学和粘附性能（拉伸强度：约14.5MPa；杨氏模量：约60.2MPa；法向和剪切粘附力：约1.81N/cm和约352.3kPa）以及良好的生物相容性。尽管单独的纳米拓扑图案或明胶涂层在干燥和潮湿环境条件下都能增强PCL的这些物理性能，但两者结合进一步强化了这些性能，表明协同线索在驱动生物医学材料力学行为方面的重要性。这种强度增强的生物医学贴片对于治疗软骨、肌腱和骨骼等组织将特别有用。
