Department of Microbiology & Immunology at The Peter Doherty Institute for Infection & Immunity, The University of Melbourne, Melbourne, Victoria 3000, Australia.
Cold Spring Harb Perspect Biol. 2021 Oct 1;13(10):a037960. doi: 10.1101/cshperspect.a037960.
Memory T-cell responses are partitioned between the blood, secondary lymphoid organs, and nonlymphoid tissues. Tissue-resident memory T (Trm) cells are a population of immune cells that remain permanently in tissues without recirculating in blood. These nonrecirculating cells serve as a principal node in the anamnestic response to invading pathogens and developing malignancies. Here, we contemplate how T-cell tissue residency is defined and shapes protective immunity in the steady state and in the context of disease. We review the properties and heterogeneity of Trm cells, highlight the critical roles these cells play in maintaining tissue homeostasis and eliciting immune pathology, and explore how they might be exploited to treat disease.
记忆 T 细胞反应存在于血液、次级淋巴器官和非淋巴组织中。组织驻留记忆 T（Trm）细胞是一类免疫细胞，它们永久存在于组织中，而不会在血液中循环。这些非循环细胞是对入侵病原体和恶性肿瘤形成的记忆反应的主要节点。在这里，我们思考 T 细胞组织驻留如何在稳态和疾病背景下定义和塑造保护性免疫。我们回顾了 Trm 细胞的特性和异质性，强调了这些细胞在维持组织内稳态和引发免疫病理中的关键作用，并探讨了如何利用它们来治疗疾病。
