• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胶质母细胞瘤干细胞的适应性转变及其对治疗的影响。

The adaptive transition of glioblastoma stem cells and its implications on treatments.

机构信息

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, P.R. China.

National Clinical Research Center for Geriatric Disorders, Changsha, P.R. China.

出版信息

Signal Transduct Target Ther. 2021 Mar 23;6(1):124. doi: 10.1038/s41392-021-00491-w.

DOI:10.1038/s41392-021-00491-w
PMID:33753720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7985200/
Abstract

Glioblastoma is the most malignant tumor occurring in the human central nervous system with overall median survival time <14.6 months. Current treatments such as chemotherapy and radiotherapy cannot reach an optimal remission since tumor resistance to therapy remains a challenge. Glioblastoma stem cells are considered to be responsible for tumor resistance in treating glioblastoma. Previous studies reported two subtypes, proneural and mesenchymal, of glioblastoma stem cells manifesting different sensitivity to radiotherapy or chemotherapy. Mesenchymal glioblastoma stem cells, as well as tumor cells generate from which, showed resistance to radiochemotherapies. Besides, two metabolic patterns, glutamine or glucose dependent, of mesenchymal glioblastoma stem cells also manifested different sensitivity to radiochemotherapies. Glutamine dependent mesenchymal glioblastoma stem cells are more sensitive to radiotherapy than glucose-dependent ones. Therefore, the transition between proneural and mesenchymal subtypes, or between glutamine-dependent and glucose-dependent, might lead to tumor resistance to radiochemotherapies. Moreover, neural stem cells were also hypothesized to participate in glioblastoma stem cells mediated tumor resistance to radiochemotherapies. In this review, we summarized the basic characteristics, adaptive transition and implications of glioblastoma stem cells in glioblastoma therapy.

摘要

胶质母细胞瘤是人类中枢神经系统中最恶性的肿瘤，总中位生存时间<14.6 个月。目前的治疗方法，如化疗和放疗，由于肿瘤对治疗的耐药性仍然是一个挑战，无法达到最佳缓解。胶质母细胞瘤干细胞被认为是导致胶质母细胞瘤治疗耐药的原因。先前的研究报告了胶质母细胞瘤干细胞的两种亚型，即神经前体细胞型和间质型，表现出对放疗或化疗的不同敏感性。间质型胶质母细胞瘤干细胞以及由此产生的肿瘤细胞对放化疗均表现出耐药性。此外，间质型胶质母细胞瘤干细胞存在两种代谢模式，即谷氨酰胺依赖型或葡萄糖依赖型，对放化疗的敏感性也不同。谷氨酰胺依赖型间质型胶质母细胞瘤干细胞比葡萄糖依赖型对放疗更敏感。因此，神经前体细胞型和间质型之间，或谷氨酰胺依赖型和葡萄糖依赖型之间的转换，可能导致肿瘤对放化疗的耐药性。此外，神经干细胞也被假设参与胶质母细胞瘤干细胞介导的对放化疗的肿瘤耐药。在这篇综述中，我们总结了胶质母细胞瘤干细胞在胶质母细胞瘤治疗中的基本特征、适应性转化及其意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3990/7985200/d353cc1e8ce6/41392_2021_491_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3990/7985200/0c6d831fea6a/41392_2021_491_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3990/7985200/75cef53967dd/41392_2021_491_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3990/7985200/d353cc1e8ce6/41392_2021_491_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3990/7985200/0c6d831fea6a/41392_2021_491_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3990/7985200/75cef53967dd/41392_2021_491_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3990/7985200/d353cc1e8ce6/41392_2021_491_Fig5_HTML.jpg

相似文献

1
The adaptive transition of glioblastoma stem cells and its implications on treatments.胶质母细胞瘤干细胞的适应性转变及其对治疗的影响。
Signal Transduct Target Ther. 2021 Mar 23;6(1):124. doi: 10.1038/s41392-021-00491-w.
2
The landscape of the mesenchymal signature in brain tumours.脑肿瘤中间质特征的全景。
Brain. 2019 Apr 1;142(4):847-866. doi: 10.1093/brain/awz044.
3
Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment.静息性胶质母细胞瘤细胞的基因特征揭示了间充质转化以及与肿瘤微环境的相互作用。
EBioMedicine. 2019 Apr;42:252-269. doi: 10.1016/j.ebiom.2019.03.064. Epub 2019 Apr 3.
4
Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma.神经前体细胞-间质转化：胶质母细胞瘤获得多疗法耐药的表型可塑性。
Int J Mol Sci. 2019 Jun 4;20(11):2746. doi: 10.3390/ijms20112746.
5
A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells.一种新型药物偶联物NEO212，靶向源自患者的神经胶质瘤癌干细胞的神经干细胞样和间充质亚型。
Cancer Lett. 2016 Feb 28;371(2):240-50. doi: 10.1016/j.canlet.2015.11.040. Epub 2015 Dec 9.
6
Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells.上皮-间充质转化标志物和 P2X7 受体的上调与 P2X7 受体刺激引起的人神经胶质瘤干细胞侵袭性增加有关。
Cells. 2019 Dec 29;9(1):85. doi: 10.3390/cells9010085.
7
Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells.联合表达分析、生物信息学和靶向蛋白质组学鉴定胶质母细胞瘤干细胞中的新潜在治疗靶点。
Oncotarget. 2015 Sep 22;6(28):26192-215. doi: 10.18632/oncotarget.4613.
8
Divergent transcriptomic signatures from putative mesenchymal stimuli in glioblastoma cells.胶质母细胞瘤细胞中推测的间充质刺激的转录组特征差异。
Cancer Gene Ther. 2024 Jun;31(6):851-860. doi: 10.1038/s41417-023-00724-w. Epub 2024 Feb 9.
9
The Impact of Hypoxia and Mesenchymal Transition on Glioblastoma Pathogenesis and Cancer Stem Cells Regulation.缺氧与间充质转变对胶质母细胞瘤发病机制及癌症干细胞调控的影响
World Neurosurg. 2016 Apr;88:222-236. doi: 10.1016/j.wneu.2015.12.032. Epub 2015 Dec 25.
10
Roles of cell fusion between mesenchymal stromal/stem cells and malignant cells in tumor growth and metastasis.间质基质/干细胞与恶性细胞之间的细胞融合在肿瘤生长和转移中的作用。
FEBS J. 2021 Mar;288(5):1447-1456. doi: 10.1111/febs.15483. Epub 2020 Jul 24.

引用本文的文献

1
Phenotypic variations in glioma stem cells: regulatory mechanisms and implications for therapeutic strategies.胶质瘤干细胞的表型变异：调控机制及其对治疗策略的影响
J Transl Med. 2025 Sep 2;23(1):984. doi: 10.1186/s12967-025-07034-9.
2
Progenitor cells, microglia, and non-coding RNAs: Orchestrators of glioblastoma pathogenesis and therapeutic resistance.祖细胞、小胶质细胞与非编码RNA：胶质母细胞瘤发病机制及治疗耐药性的调控者
Noncoding RNA Res. 2025 Aug 5;15:85-99. doi: 10.1016/j.ncrna.2025.07.007. eCollection 2025 Dec.
3
Stem cell therapies and glioma stem cells in glioblastoma: a systematic review of current challenges and research directions.

本文引用的文献

1
Emerging role of tumor cell plasticity in modifying therapeutic response.肿瘤细胞可塑性在改变治疗反应中的新作用。
Signal Transduct Target Ther. 2020 Oct 7;5(1):228. doi: 10.1038/s41392-020-00313-5.
2
Functional characterization of SOX2 as an anticancer target.SOX2 的功能特征作为一种抗癌靶标。
Signal Transduct Target Ther. 2020 Jul 29;5(1):135. doi: 10.1038/s41392-020-00242-3.
3
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy.单细胞 RNA 测序揭示胶质母细胞瘤再现了正常的神经发育层次结构。
胶质母细胞瘤中的干细胞疗法与胶质瘤干细胞：当前挑战及研究方向的系统综述
Int J Emerg Med. 2025 Aug 6;18(1):144. doi: 10.1186/s12245-025-00921-4.
4
Unlocking the secret of glioblastoma multiforme: the role of lactylation in tumor progression, drug resistance and immune microenvironment.揭开多形性胶质母细胞瘤的秘密：乳酰化在肿瘤进展、耐药性和免疫微环境中的作用
Cancer Cell Int. 2025 Aug 7;25(1):299. doi: 10.1186/s12935-025-03933-5.
5
Natural Compounds That Target Glioma Stem Cells.靶向胶质瘤干细胞的天然化合物。
NeuroSci. 2025 Jun 5;6(2):52. doi: 10.3390/neurosci6020052.
6
Targeting the MDK/c-Myc complex to overcome temozolomide resistance in glioma.靶向MDK/c-Myc复合物以克服胶质瘤中的替莫唑胺耐药性。
Clin Transl Med. 2025 Jun;15(6):e70359. doi: 10.1002/ctm2.70359.
7
Metabolic reprogramming in glioblastoma: a rare case of recurrence to scalp metastasis.胶质母细胞瘤中的代谢重编程：一例罕见的复发至头皮转移病例。
BJC Rep. 2025 Apr 24;3(1):27. doi: 10.1038/s44276-025-00134-5.
8
Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations.对胶质瘤细胞异质性和代谢适应性的单细胞及空间转录组学见解
Front Immunol. 2025 Apr 4;16:1561388. doi: 10.3389/fimmu.2025.1561388. eCollection 2025.
9
Understanding Neovascularization in Glioblastoma: Insights from the Current Literature.了解胶质母细胞瘤中的新生血管形成：来自当前文献的见解。
Int J Mol Sci. 2025 Mar 19;26(6):2763. doi: 10.3390/ijms26062763.
10
MAGL targeted PROTAC degrader simultaneously enhances P53 for synergistic treatment of glioblastoma stem cell.MAGL靶向的PROTAC降解剂同时增强P53以协同治疗胶质母细胞瘤干细胞。
Cell Death Discov. 2025 Mar 20;11(1):109. doi: 10.1038/s41420-025-02392-1.
Nat Commun. 2020 Jul 8;11(1):3406. doi: 10.1038/s41467-020-17186-5.
4
Organoid Models of Glioblastoma to Study Brain Tumor Stem Cells.用于研究脑肿瘤干细胞的胶质母细胞瘤类器官模型
Front Cell Dev Biol. 2020 Apr 16;8:220. doi: 10.3389/fcell.2020.00220. eCollection 2020.
5
Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients.过氧化物酶体增殖物激活受体 γ 作为间充质型神经胶质瘤患者的治疗靶点。
Exp Mol Med. 2020 Apr;52(4):629-642. doi: 10.1038/s12276-020-0413-1. Epub 2020 Apr 13.
6
The Quiescent Metabolic Phenotype of Glioma Stem Cells.胶质瘤干细胞的静止代谢表型
J Proteomics Bioinform. 2019;12(6):96-103. doi: 10.35248/0974-276x.19.12.502. Epub 2019 Aug 13.
7
Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles.神经母细胞瘤和间充质胶质瘤干细胞在剪接和长链非编码RNA谱方面存在重大差异。
NPJ Genom Med. 2020 Jan 16;5:2. doi: 10.1038/s41525-019-0108-5. eCollection 2020.
8
Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αβ Axis.寨卡病毒通过 SOX2-整合素 αβ 轴靶向神经胶质瘤干细胞。
Cell Stem Cell. 2020 Feb 6;26(2):187-204.e10. doi: 10.1016/j.stem.2019.11.016. Epub 2020 Jan 16.
9
Metabolic regulation of neurodifferentiation in the adult brain.成年大脑中神经分化的代谢调节。
Cell Mol Life Sci. 2020 Jul;77(13):2483-2496. doi: 10.1007/s00018-019-03430-9. Epub 2020 Jan 7.
10
Autofluorescence of NADH is a new biomarker for sorting and characterizing cancer stem cells in human glioma.NADH 的自发荧光是一种新的生物标志物，可用于分选和鉴定人类神经胶质瘤中的癌症干细胞。
Stem Cell Res Ther. 2019 Nov 20;10(1):330. doi: 10.1186/s13287-019-1467-7.